Synthesis of Novel Hybrid Lonidamine-Coumarin Derivatives and Their Anticancer Activities

İpek, Özgecan Şavluğ; Sucu, Bilgesu Onur; Gül, Şeref; Yolaçan, Çiğdem; Güzel, Mustafa

doi:10.1016/j.molstruc.2023.135114

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…Measurements of the cytotoxic effect of LD and hybrid lonidamine-coumarin in the MCF-7 and A549 cell lines gave IC 50 values for LD and hybrid lonidamine-coumarin as 239.4 µM, 33.12 µM for MCF-7 and 444 µM and 222.8 µM for A549, respectively. Based on molecular docking studies, a good binding affinity to HK2 was identified for hybrid lonidamine-coumarin, so this may confirm HK2 as a molecular target for this agent [48].…”

Section: Metformin (Met)mentioning

confidence: 86%

Targeting HK2 in Anticancer Therapy

Walczak

2024

BJSTR

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Section: Metformin (Met)mentioning

confidence: 86%

Targeting HK2 in Anticancer Therapy

Walczak

2024

BJSTR

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“…It is possible that combining the coumarin moiety with other antimicrobial agents is a potential approach for developing new therapeutics. Modification of coumarins is of great interest due to their distinctive structural characteristics and pharmacological properties, such as antiviral [ 50 , 51 ], anti-inflammatory [ 52 , 53 ], antibacterial [ 54 ], anticancer [ 55 , 56 ], and antioxidant [ 57 ] activities. Several synthesized molecules containing coumarin rings have been reported to be effective against multi-drug resistant (MDR) microorganisms [ 58 , 59 ].…”

Section: Natural Productsmentioning

confidence: 99%

Antifungal Activities of Natural Products and Their Hybrid Molecules

Khwaza,

Aderibigbe

2023

Pharmaceutics

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The increasing cases of drug resistance and high toxicity associated with the currently used antifungal agents are a worldwide public health concern. There is an urgent need to develop new antifungal drugs with unique target mechanisms. Plant-based compounds, such as carvacrol, eugenol, coumarin, cinnamaldehyde, curcumin, thymol, etc., have been explored for the development of promising antifungal agents due to their diverse biological activities, lack of toxicity, and availability. However, researchers around the world are unable to fully utilize the potential of natural products due to limitations, such as their poor bioavailability and aqueous solubility. The development of hybrid molecules containing natural products is a promising synthetic approach to overcome these limitations and control microbes’ capability to develop resistance. Based on the potential advantages of hybrid compounds containing natural products to improve antifungal activity, there have been different reported synthesized hybrid compounds. This paper reviews different literature to report the potential antifungal activities of hybrid compounds containing natural products.

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“…It has been figured out during the literature survey that in reproducing the experimental values in geometry, dipole moment, vibrational frequency, etc. DFT has a precise accuracy [6][7][8][9][10][11][12]. The aim of this study is to investigate the energetic and structural properties of the 8-t-buthyl-4-methyl-2H-chromen-2-one (Fig.…”

Section: Introductionmentioning

confidence: 99%

Quantum Chemical and Biological Properties of Coumarin Derivative Compound

SARAÇ,

ÇETİN

2023

Journal of Physical Chemistry and Functional Materials

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This work presents the characterization of 8-t-buthyl-4-methyl-2H- chromen 2-one by quantum chemical calculations and spectral techniques. The molecular geometry, vibrational frequencies and gauge including atomic orbital (GIAO) 1H and 13C NMR chemical shift values of title compound in the ground state have been calculated using the density functional method (B3LYP) with the 6-31G(d) basis set. The theoretical vibrational frequencies and chemical shift values show good agreement with experimental values. In addition, DFT calculations of molecular electrostatic potentials and frontier molecular orbitals of the title were carried out at the B3LYP/6-31G(d) level of theory. The title compound was screened for antibacterial, antifungal and antioxidant activities.

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Synthesis of Novel Hybrid Lonidamine-Coumarin Derivatives and Their Anticancer Activities

Cited by 6 publications

References 56 publications

Targeting HK2 in Anticancer Therapy

Targeting HK2 in Anticancer Therapy

Antifungal Activities of Natural Products and Their Hybrid Molecules

Quantum Chemical and Biological Properties of Coumarin Derivative Compound

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