Synthesis of novel immunomodulatory 1,4-disubstituted bis-1,2,3-triazoles by using click chemistry and their intracellular mechanism of action

Quinazolinone-1,2,3-triazole-acetamide conjugates as potent α-glucosidase inhibitors: synthesis, enzyme inhibition, kinetic analysis, and molecular docking study

“…1,2,3-Triazole-based pharmacophore according to its chemical and physiological properties got much attention in medicinal chemistry due to its easy synthetic procedure and versatile functions as a key entity in design and synthesis of pharmacologically active agents. 1,2,3-Triazole derivatives are known to possess various biological activities such as antimicrobial, 21 anticancer, 22 anti-inflammatory, 23 and anti-Alzheimer's 24 properties. Phenoxy-1,2,3-triazole moiety was also introduced as promising anti-α-glucosidase inhibitors with provided optimum conformation to penetrate the deep gorge of the binding site and participate in several interactions with the binding site to get the suppressed conformer of the enzyme.…”