Synthesis of novel macrocyclic Schiff's‐base and its complexes having N₂O₂ group of donor atoms. Characterization and anticancer screening are studied

Abstract

Novel Schiff base [N′,N′″-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(methanylylidene))di(benzohydrazide)] was formed by the condensation reaction of benzohydrazide with 2,2′-(ethane-1,2-diylbis(oxy))dibenzaldehyde. Its reaction with various metal ions was studied and the structures of the new products were characterized using common analytical and spectroscopic methods. All the metal complexes have pronounced anticancer activities. The antimicrobial activities against Gram-negative and Gram-positive bacteria were investigated.

Structural, spectroscopic, molecular docking, thermal and DFT studies on metal complexes of bidentate orthoquinone ligand

“…It also showed three transitions 2 B 1g → 2 B 2g , 2 B 1g → 2 E g and 2 B 1g → 2 A 1g due to the states of octahedral 2 E g and 2 T 2g of metal ion (d 9 ) split. This observation was in agreement the Cu (II) d–d transitions were normally close in energy and the magnetic value of Cu (II) complex was 1.84 BM in the range for octahedral geometry …”

“…The spectrum of Mn (II) complex showed bands at 16,583, 17,421 and 24, 154 cm −1 which refer to 4 T 1g → 6 A 1g , 4 T 2g (G) → 6 A 1g and 4 T 1g (D) → 6 A 1g transitions, respectively . The complex had octahedral geometry, which confirmed by magnetic moment.…”

“…The Fe (III) chelate spectrum have bands at 14,658, 26,675 and 35,759 cm −1 to the 6 A 1g → T 2g (G) and 6 A 1g → 5 T 1g transitions in octahedral geometry with magnetic moment value 5.22 BM and involving d 2 sp 3 hybridization …”

Coordination behaviour and biological activity studies involving theoretical docking of bis‐Schiff base ligand and some of its transition metal complexes

“…This has led to a variety of applications related to their biological activity. The electron‐donor properties of the Schiff base ligands, functional groups in their structures and their position in the coordination sphere of their chelates were the main factors affecting their reactivates in various studies . It is known that copper complexes show anti‐nuclear activity and also they have an effect against rheumatoid arthritis .…”

Spectroscopic, thermal, biological activity, molecular docking and density functional theoretical investigation of novel bis Schiff base complexes

“…[19,20] Coordinated that occurs between ligand and transition metal ions yielding many complexes which have been shown to exhibit interesting magnetic susceptibility and luminescence spectra. [21] Docking methodology [22,23] aims to predict the experimental binding modes and affinities of small molecules within the binding site of particular receptor targets and is currently used as a standard computational tool in drug design for lead compound optimization and in virtual screening studies to find novel biologically active molecules. The basic tools of a docking methodology include a search algorithm and an energy scoring function for generating and evaluating ligand poses.…”