Synthesis of novel N-, S-substituted-polyhalo-1, 3-butadienes and crystal structure of dibutadienyl homopiperazine

The Vinylic SN Reactions of Nitrodienes with Heteroatom‐Substituted Nuchleophilies and Their Structural Studies

“…). 13 C NMR peaks of disubstituted butadienyl compounds 12 , 24a , and 24b agree well with the similar compounds reported earlier .…”

“…However, in the crystal structure of mono(thio)substituted nitrodienes reported in previous studies, it was noted that mono(thio)substituted nitrobutadienes were ( E )‐isomers and N , S ‐substituted nitrobutadienes were also ( E )‐isomers. As a consequence, it might be thought that the derived new S ‐ and N , S ‐substituted nitrodiene products were probably ( E )‐isomers . In this study, single crystal structures of compounds 3a and 21a showed that mono(thio)‐ and N , S ‐substituted‐3‐nitro‐butadiene compounds such as 3a and 21a were ( E )‐isomer.…”

“…During the past years, we have published the syntheses of a wide range of diverse substance classes, applying this useful starting material . Some physiological potential can be expected, as even 3‐nitrobutadienes have antiviral and also cytotoxic properties .…”

Mechanisms of the Reaction between Polyhalogenated Nitrobutadienes and Electron-Deficient Anilines: Computational Modeling

“…They also react as dienophiles in Diels–Alder reactions . Nitro-substituted polyhalogeno-1,3-butadienes are members of a new class of nitroalkenes called polyhalogenated nitrobutadienes, which became the topic of recent investigations because of their interesting chemical and biological properties. , Generally the choice of building block is 2-nitroperchloro-1,3-butadiene 1a , which is easily accessible by the introduction of an activating and directing nitro group into 2H-pentachloro-1,3-butadiene. , …”