Synthesis of novel piperazine-based bis(thiazole)(1,3,4-thiadiazole) hybrids as anti-cancer agents through caspase-dependent apoptosis

Abstract

Compound 9i as a novel piperazine-based bis(thiazoles) and bis(thiadiazole) derivative was synthesized and characterized as potent EGFR inhibitor with promising cytotoxicity against HCT-116 cells through apoptosis.