Synthesis of Novel Pyrazole, Coumarin and Pyridazine Derivatives Evaluated as Potential Antimicrobial and Antifungal Agents

Synthesis and Biological Evaluation of New Fused Isoxazolo[4,5‐d] Pyridazine Derivatives

“…Reaction of 7 with thiourea gave the thiol derivative 9, which on treatment with an aqueous solution of sodium hydrogen sulfate and sodium nitrite yielded the disulfide 10. In accordance with the suggested structure, the 13 …”

“…The 13 C NMR data of compounds 2 and 4 are summarized in Table 2 and the chemical shift values conform to the suggested structures. The MS of the pyridazinone 2a showed a molecular ion as the base peak at m/z 165 while for 2b the base peak was the [M-NHSO 2 C 6 H 4 NCO] species and the molecular ion was only 25%.…”

“…Isoxazoles, 1-6 triazoles 7-10 and pyridazines [11][12][13][14][15][16] are biologically important heterocyclic compounds. Some of these compounds have antibacterial activity better than carbenicillin against Gram-negative strains 17 others are used as antimicrobial agents.…”

Biological activities of steroidal alkaloids isolated fromSolanum leucocarpum

“…The tests were carried out in triplicate and the mean of the inhibition zones were calculated. The minimum inhibitory concentrations (MICs) were determined as the lowest concentration of the tested compounds that inhibited bacterial growth on the plate (Wardakhan & Louca, 2007).…”

FACILE SYNTHESIS OF ISOXAZOLES AND PYRAZOLES FROM SS-Diketohydrazones

“…In fact, several isoxazoles [1][2][3][4][5][6][7] and pyrazoles [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] have a remarkable importance in medicine and particularly pyrazole's chemistry has been extended toward the catalysis 23 and coordination chemistry [24][25] . On the other hand, it is well known that β-diketones as pentane-2,4-dione, CH 2 (COCH 3 ) 2 , in basic medium, may couple with substituted diazonium salts [26][27] yielding series of compounds that belong to the β-diketohydrazones family, namely 3-[2-(R 1 -phenyl)hydrazono)]pentane-2,4-dione, see Schemes.…”