Synthesis of Novel Pyrido[1,2-&lt;i&gt;a&lt;/i&gt;]pyrimidine-3-carboxamide Derivatives and Their Anticancer Activity

Kumar, Gopinatha Suresh; Dev, G. Jitender; Kumar, Nitin; Swaroop, Desireddy Krishna; Chandra, Yedla Poorna; Kumar, C. Ganesh; Narsaiah, B.

doi:10.1248/cpb.c15-00219

Cited by 10 publications

(1 citation statement)

References 21 publications

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“…In the SAR, it was established that thien-2-yl group in place of phenyl group at 6th position of the compounds showed better activity (Fig. 26) [81].…”

Section: Pyrido Pyrimidine Derivatives Pyrido [12-a]pyrimidine Derivativesmentioning

confidence: 99%

Pyrimidine: a review on anticancer activity with key emphasis on SAR

2021

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Background Cancer is a global health challenge, it impacts the quality of life and its treatment is associated with several side effects. Resistance of the cancer cells to the existing drugs has led to search for novel anticancer agents. Pyrimidine, a privileged scaffold, is part of living organisms and plays vital role in various biological procedures as well as in cancer pathogenesis. Due to resemblance in structure with the nucleotide base pair of DNA and RNA, it is recognized as valuable compound in the treatment of cancer. Main text Many novel pyrimidine derivatives have been designed and developed for their anticancer activity in the last few years. The present review aims to focus on the structure activity relationship (SAR) of pyrimidine derivatives as anticancer agent from the last decade. Conclusion This review intends to assist in the development of more potent and efficacious anticancer drugs with pyrimidine scaffold. Graphical abstract

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“…In the SAR, it was established that thien-2-yl group in place of phenyl group at 6th position of the compounds showed better activity (Fig. 26) [81].…”

Section: Pyrido Pyrimidine Derivatives Pyrido [12-a]pyrimidine Derivativesmentioning

confidence: 99%

Pyrimidine: a review on anticancer activity with key emphasis on SAR

2021

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Rh(III)‐Catalyzed C6‐Selective C−H 3‐Oxoalkylation of 2‐Pyridones with Allylic Alcohols

Shan

Huang

et al. 2022

Asian J Org Chem

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Rhodium(III)-catalyzed C6-selective CÀ H 3-oxoalkylation of 2-pyridones was developed with commercially available allylic alcohols as the 3-oxoalkyl sources. In this reaction, the excellent site selectivity was controlled by the 2-pyridyl directing group on the nitrogen of the pyridone ring. This reaction features good functional group tolerance and the generation of 6-(3-oxoalkyl) pyridones in moderate to good yields.

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Tandem Ring Opening/Cyclization of trans‐2‐Aryl‐3‐nitrocyclopropane‐1,1‐dicarboxylates with 2‐Aminopyridines: Access to Pyrido[1,2‐a]pyrimidin‐4‐one Derivatives

Selvi

Srinivasan

2017

Eur J Org Chem

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A tandem ring‐opening/cyclization reaction of trans‐2‐aryl‐3‐nitrocyclopropane‐1,1‐dicarboxylates with 2‐aminopyridines was discovered. The reaction did not require the assistance of any catalyst and proceeded more efficiently in water than in organic solvents. This strategy afforded pyrido[1,2‐a]pyrimidin‐4‐one derivatives having a carboxylate group at C3 in 62–90 % yields.

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Synthesis of Novel Pyrido[1,2-<i>a</i>]pyrimidine-3-carboxamide Derivatives and Their Anticancer Activity

Cited by 10 publications

References 21 publications

Pyrimidine: a review on anticancer activity with key emphasis on SAR

Pyrimidine: a review on anticancer activity with key emphasis on SAR

Rh(III)‐Catalyzed C6‐Selective C−H 3‐Oxoalkylation of 2‐Pyridones with Allylic Alcohols

Tandem Ring Opening/Cyclization of trans‐2‐Aryl‐3‐nitrocyclopropane‐1,1‐dicarboxylates with 2‐Aminopyridines: Access to Pyrido[1,2‐a]pyrimidin‐4‐one Derivatives

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