Synthesis of Novel Pyrimido[4,5-b] Quinolines Containing Benzyloxy and 1,2,3-Triazole Moieties by DABCO as a Basic Catalyst

Abstract

DABCO was used as a basic and inexpensive catalyst for the synthesis of some new benzyloxy pyrimido[4,5-b]quinoline derivatives and 1,2,3- triazole-fused pyrimido[4,5-b]quinolines by the one-pot multi-component reaction of various benzyloxy benzaldehydes or benzylic −1,2,3-triazol-4-yl-methoxy benzaldehydes with dimedone and 6-amino-1,3-dimethyluracil at 90 °C under the solvent-free condition.

A Highly Efficient Strategy for One-Pot and Pseudo-Six-Component Synthesis of Hexahydroquinolines

“…Heterocycles consist of a cyclic system with one or more (same or different) heteroatoms in their rings. − Heterocyclic compounds were shown to be a specific category of compounds with natural origin as well as chemical, medicinal, and industrial significance. , They seem to be significant and useful agents against different types of medical disorders. As previously reported in the literature, approximately 60% of the drugs employed for cancer therapy contain heterocyclic scaffolds.…”

A green synthesis of pyrimido[4,5-b]quinolines and pyrido[2,3-d]pyrimidines via a mechanochemical approach

“…[38][39][40] Numerous one-pot protocols have been reported due to the significant biological and synthetic importance of pyrimido [4,5-b]quinoline derivatives; however, these protocols either use high temperatures, produce lower yields, or take a longer time to complete. Very recently, Soheila Esmaili and coworkers 41 reported DABCO catalyzed synthesis of pyrimido [4,5b]quinolones; this required a high mol% of catalyst, a long reaction time, and a high temperature (Scheme 1(Ia)). Next, Zarei and coworkers reported the same class of compounds 42 using a phosphorous acid anchored nanoporous catalyst [MIL-100(Cr)/NHEtN(CH 2 PO 3 H 2 ) 2 ], but this required a long reaction time, high temperature, and the use of a toxic solvent (Scheme 1(Ib)).…”

Synthesis and characterization of Co-MOF@Ag2O nanocomposite and its application as a nano-organic catalyst for one-pot synthesis of pyrazolopyranopyrimidines

“…The most remarkable attribute of MCRs is that almost all the parts and features of the reactants can be found in the newly formed product indicative of low by-product formation making them wonders of reaction design and efficiency 15 . The development of new MCRs, and improvement of known multi-component reactions are due to their outstanding advantages such as simple operation, high selectivity, high efficiency, high atom economy, reducing the generate of by-products and waste, cost-effectiveness, Saving the chemical materials, time, energy and solvent, eco-friendly nature 18 – 24 .…”