Synthesis of Novel Series of 6‐Chloro‐1,1‐dioxo‐1,4,2‐benzodithiazine Derivatives with Potential Biological Activity

Abstract

A series of 6′‐chloro‐1′,1′‐dioxo‐2′H‐spiro[benzo[d][1,3,7]oxadiazocine‐4,3′‐(1,4,2‐benzodithiazine)]‐2,6(1H,5H)‐dione derivatives 2a, 2b and 3a, 3b have been synthesized starting from 3‐aminobenzodithiazines 1a, 1b and isatoic anhydride. Subsequent reactions of 2a with 3‐chlorophenyl isocyanate gave condensation products 4 and 5. Compound 2a was also converted into 3‐(2‐aminobenzamido)‐6‐chloro‐7‐methyl‐1,1‐dioxo‐1,4,2‐benzodithiazine derivatives 6, 7, 8, 9, 10. The mechanisms of the reactions are discussed.