Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3- d ]pyrimidine derivatives as promising anticancer and antibacterial agents

Kumar, Rajnish; Dev, G. Jitender; Ravikumar, N.; Swaroop, Desireddy Krishna; Debanjan, B.; Gandu, Bharath; Narsaiah, B.; Jain, Sarthak; Rao, A. Gangagni

doi:10.1016/j.bmcl.2016.04.038

Cited by 83 publications

(19 citation statements)

References 31 publications

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“…Kumar et al . prepared a series of novel pyrido[2,3d]pyrimidine derivatives with a long carbon chain and screened for their antibacterial activity.…”

Section: Othersmentioning

confidence: 99%

Recent Development of Pyrimidine‐Containing Antimicrobial Agents

Zhuang

2020

ChemMedChem

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Multidrug-resistant bacterial infections have become an important cause of clinical death in the twenty-first century. Much effort has been made to overcome this challenge. The discovery of novel antimicrobial compounds, as well as the rational use of antibacterial drugs with different structure types and mechanisms, is helping to deal with bacterial resistance. Currently, pyrimidine-containing agents are the major areas of new antibacterial drug discovery. Given their good activities and diverse mechanisms of action, many pyrimidine-containing heterocyclic compounds have become the focus of interest for many scientists. In addition, pyrimidine structure is an important part of many endogenous substances, which is an advantage that allows pyrimidine derivatives to interact with genetic materials, enzymes and other biopolymeric substances in the cell. Scientists have focused on the discovery and structural optimization of pyrimidine derivatives, which has resulted in the discovery of many novel pyrimidine derivatives with intriguing profiles. Herein we summarize the therapeutic potentials of pyrimidine compounds that are promising for antimicrobial applications over the last decade. In particular, the relationships between the structures of modified pyrimidines and their antimicrobial activity are systematically discussed.

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“…Kumar et al . prepared a series of novel pyrido[2,3d]pyrimidine derivatives with a long carbon chain and screened for their antibacterial activity.…”

Section: Othersmentioning

confidence: 99%

Recent Development of Pyrimidine‐Containing Antimicrobial Agents

Zhuang

2020

ChemMedChem

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“…Compounds b29 and b30 showed highest activity against PANC-1 (pancreatic cancer) and A549 (lung cancer) cell lines respectively (Table 26 , Fig. 7 ) [ 34 ].…”

Section: Biological Significance Of Pyrimidine Scaffoldsmentioning

confidence: 99%

Therapeutic potential of heterocyclic pyrimidine scaffolds

Kumar

2018

Chemistry Central Journal

158

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Heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly and economically useful as therapeutic agents. Comprehensive research on diverse therapeutic potentials of heterocycles compounds has confirmed their immense significance in the pathophysiology of diseases. Heterocyclic pyrimidine nucleus, which is an essential base component of the genetic material of deoxyribonucleic acid, demonstrated various biological activities. The present review article aims to review the work reported on therapeutic potentials of pyrimidine scaffolds which are valuable for medical applications during new generation.

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“…Many of the fused pyridine compounds have been proven as valuable candidates possessing anti-bacterial (Elagamey, Sattar, El-Taweel, & Said, 2015), anti-fungal (Hanafy, 2011), anti-microbial (Paresh & Yogesh, 2015), antioxidant (Farghaly, Abass, Abdalla, & Mahgoub, 2011;Flefel et al, 2014), anti-cancer (Bladt, Frisvad, Knudsen, & Larsen, | 465 LAVANYA et AL. 2013;Naresh Kumar et al, 2016), anti-psychotic (Swain et al, 1992), anti-inflammatory (Hend, At-Allah, A-Rahman, & El-Gazza, 2008;Piero & Lucio, 2012), anti-leishmanial (Samai, Nandi, Chowdhury, & Singh, 2011), anti-viral (Tai et al, 2014, anti-hypersensitive (Smith et al, 1989), anticonvulsants (Kaminski, Obniska, Zagorska, & Maciag, 2006), anti-malarial (Davoll, Clarke, & Elslage, 1972), potassium channel openers (Gadwood et al, 1993), anti-diabetic (Sarges, Bordner, Dominy, Peterson, & Whipple, 1985) and anti-tumour activities (Mohamed & Giuseppe, 2016). A few of previously reported bio-active fused compounds (A-D) were represented in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

“…Among the heterocyclic compounds, pyridine and their analogues are the most prevalent structural units due to their wide spectrum of applications (Song, Huang, Yi, & Zhang, ), in natural products (Michael, ), pharmaceutical (Baumann & Baxendale, ; Vitaku, Smith, & Njardarson, ), agrochemical (Guan, Liu, Sun, & Xie, ) and material science (Desimoni, Faita, & Quadrelli, ; Gillissen et al., ). Many of the fused pyridine compounds have been proven as valuable candidates possessing anti‐bacterial (Elagamey, Sattar, El‐Taweel, & Said, ), anti‐fungal (Hanafy, ), anti‐microbial (Paresh & Yogesh, ), anti‐oxidant (Farghaly, Abass, Abdalla, & Mahgoub, ; Flefel et al., ), anti‐cancer (Bladt, Frisvad, Knudsen, & Larsen, ; Naresh Kumar et al., ), anti‐psychotic (Swain et al., ), anti‐inflammatory (Hend, At‐Allah, A‐Rahman, & El‐Gazza, ; Piero & Lucio, ), anti‐leishmanial (Samai, Nandi, Chowdhury, & Singh, ), anti‐viral (Tai et al., ), anti‐hypersensitive (Smith et al., ), anti‐convulsants (Kaminski, Obniska, Zagorska, & Maciag, ), anti‐malarial (Davoll, Clarke, & Elslage, ), potassium channel openers (Gadwood et al., ), anti‐diabetic (Sarges, Bordner, Dominy, Peterson, & Whipple, ) and anti‐tumour activities (Mohamed & Giuseppe, ). A few of previously reported bio‐active fused compounds ( A–D ) were represented in Figure .…”

Section: Introductionmentioning

confidence: 99%

One pot multi‐component synthesis of functionalized spiropyridine and pyrido[2,3‐d]pyrimidine scaffolds and their potent in‐vitro anti‐inflammatory and anti‐oxidant investigations

2018

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A new series of functionalized fused pyridines 4(a–i) and fused pyrido[2,3‐d]pyrimidines 8(a–c) were designed and synthesized through a multi‐component reaction where in pyridine ring formation step plays a key role. All the newly formed compounds were well characterized by spectral techniques such as FTIR, 1HNMR, 13CNMR, HRMS and XRD. The potential therapeutic activities such as anti‐inflammatory activity by protein denaturation and RBC membrane stabilization methods, and anti‐oxidant activity by DPPH scavenging method of the newly synthesized compounds were studied. Interestingly, in‐vitro testing of these compounds reveals that the compounds 4d, 4g, 4i, 8a and 8b showed comparable anti‐inflammatory activity with respect to the standard drug, diclofenac. Similarly, fused pyridine 4f showed excellent anti‐oxidant activity when compared with the standard, ascorbic acid.

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Synthesis of novel triazole/isoxazole functionalized 7-(trifluoromethyl)pyrido[2,3- d ]pyrimidine derivatives as promising anticancer and antibacterial agents

Cited by 83 publications

References 31 publications

Recent Development of Pyrimidine‐Containing Antimicrobial Agents

Recent Development of Pyrimidine‐Containing Antimicrobial Agents

Therapeutic potential of heterocyclic pyrimidine scaffolds

One pot multi‐component synthesis of functionalized spiropyridine and pyrido[2,3‐d]pyrimidine scaffolds and their potent in‐vitro anti‐inflammatory and anti‐oxidant investigations

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