Synthesis of novel tripodal-benzimidazole from 2,4,6-tris(p-formylphenoxy)-1,3,5-triazine: Structural, electrochemical and antimicrobial studies

Koç, Ziya Erdem; Bingöl, Haluk; Saf, Ahmet Özgür; Torlak, Emrah; Coşkun, Ahmet

doi:10.1016/j.jhazmat.2010.07.018

Cited by 39 publications

(16 citation statements)

References 34 publications

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“…Many of the dopamine containing compounds have also exhibited antimicrobial and antibacterial activities [9][10][11][12][13][14]. These are also used as bridging agents to synthesize herbicides and also in the production of drugs and polymers [12,10,[15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of dopamine substitue tripodal trinuclear [(salen/salophen/salpropen)M] (MCr(III), Mn(III), Fe(III) ions) capped s-triazine complexes: Investigation of their thermal and magnetic properties

Uysal

Koç

2016

Journal of Molecular Structure

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of dopamine substitue tripodal trinuclear [(salen/salophen/salpropen)M] (MCr(III), Mn(III), Fe(III) ions) capped s-triazine complexes: Investigation of their thermal and magnetic properties

Uysal

Koç

2016

Journal of Molecular Structure

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“…[49] According to Koc et al, [50] four new benzimidazole compounds were prepared by using TRIPOD and various diamines, resulting in products called "tripodal benzimidazoles". [49] According to Koc et al, [50] four new benzimidazole compounds were prepared by using TRIPOD and various diamines, resulting in products called "tripodal benzimidazoles".…”

Section: Tripodal-benzimidazole Compoundsmentioning

confidence: 99%

“…In recent years much research hasb een devoted to the design and synthesis of 1,3,5-triazine derivatives because of their potentiala ntibacteriala ctivity.T he reaction of trichloro-1,3,5-triazine with 4-hydroxybenzaldehyde in benzene generated acompound knowna sT RIPOD. [49] According to Koc et al, [50] four new benzimidazole compounds were prepared by using TRIPOD and various diamines, resulting in products called "tripodal benzimidazoles". In this series, compounds 71 and 72 exhibited more potent activity against S. aureus and B. subtilis than the other compounds generated.…”

Section: Tripodal-benzimidazole Compoundsmentioning

confidence: 99%

Recent Development of Benzimidazole‐Containing Antibacterial Agents

Song

2016

ChemMedChem

128

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Clinically significant antibiotic resistance is one of the greatest challenges of the twenty-first century. However, new antibacterial agents are currently being developed at a much slower pace than our growing need for such drugs. Given their diverse biological activities and clinical applications, many bioactive heterocyclic compounds containing a benzimidazole nucleus have been the focus of interest for many researchers. The benzimidazole nucleus is a structural isostere of naturally occurring nucleotides. This advantage allows benzimidazoles to readily interact with the various biopolymers found in living systems. In view of this situation, much attention has been given to the exploration of benzimidazole-based antibacterial agents, leading to the discovery of many new chemical entities with intriguing profiles. In this minireview we summarize novel benzimidazole derivatives active against various bacterial strains. In particular, we outline the relationship between the structures of variously modified benzimidazoles and their antibacterial activity.

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“…Many s-triazine containing compounds are used as anti-protozoals, 5 anticancer agents, 6 estrogen receptor modulators, 7 antimalarials, 8 cyclin-dependent kinase modulators, 9 and antimicrobials. 10 This scaffold has attracted researchers for the design of new compounds, owing to its structural symmetry and the ease of displacing the chlorine atoms of cyanuric chloride to obtain symmetrical or non-symmetrical compounds. 11,12 Compounds bearing the 1,3,5-triazine heterocycle have shown remarkable antitumor activities, and some have reached clinical trial phases.…”

Section: Introductionmentioning

confidence: 99%

Radioiodination and biological distribution of a new s‐triazine derivative for tumor uptake evaluation

Motaleb

Ibrahim

Sarhan

et al. 2018

Labelled Comp Radiopharmac

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A newly synthesized s-triazine derivative 1,1',1″-(((1,3,5-triazine-2,4,6-triyl) tris (azanediyl)) tris (benzene-4,1-diyl))tris (ethan-1-one), (1), was synthesized as a part of an ongoing research for development of novel s-triazine-based radiopharmaceuticals. In-vitro cell viability assay against different human cancer cell lines showed very promising inhibitory activity of the synthesized compound. This finding encouraged the radioiodination of 1 to study the degree of its localization in tumor site for evaluating the possibility of its use as a tumor imaging agent. The biodistribution study showed good localization of the radioiodinated derivative 2 at tumor site following i.v. administration in solid tumor-bearing mice. Finally, in a trial to understand the mechanism of the anticancer effect exerted by 1, a target prediction study and a docking study were performed. The results of the first study showed that focal adhesion kinase is a possible target for compound 1 and the docking study confirmed successful binding of both compound 1 and its radioiodinated derivative 2 to the binding site of focal adhesion kinase. As a conclusion, the results of this study suggest that, compound 2 could be used as a potential agent for tumor imaging after preclinical trials.

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Synthesis of novel tripodal-benzimidazole from 2,4,6-tris(p-formylphenoxy)-1,3,5-triazine: Structural, electrochemical and antimicrobial studies

Cited by 39 publications

References 34 publications

Synthesis and characterization of dopamine substitue tripodal trinuclear [(salen/salophen/salpropen)M] (MCr(III), Mn(III), Fe(III) ions) capped s-triazine complexes: Investigation of their thermal and magnetic properties

Synthesis and characterization of dopamine substitue tripodal trinuclear [(salen/salophen/salpropen)M] (MCr(III), Mn(III), Fe(III) ions) capped s-triazine complexes: Investigation of their thermal and magnetic properties

Recent Development of Benzimidazole‐Containing Antibacterial Agents

Radioiodination and biological distribution of a new s‐triazine derivative for tumor uptake evaluation

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