Synthesis of nucleoside analogs and new Tat protein inhibitors

Abstract

Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on thiaazaheterocycle systems from thiaazabutadienes are discussed. The preparation of new N-and C-nucleosides is presented. In the second part, the discovery of aromatic polycyclic derivatives as inhibitors of Tat protein is exposed. The work presented takes into account the participation of African partners in further synthetic research programs carried out in collaboration with the laboratory of Nantes.

An Efficient Route to Pyrimidine Nucleoside Analogues by [4 + 2] Cycloaddition Reaction

“…Considerable efforts have been undertaken to exploit synthetic routes to these compounds . In the course of the preparation of nucleosides, base moieties are generally introduced by substitution or more rarely by construction . Conventionally, synthesis of N -linked oligosaccharides has been achieved by coupling of activated glycosyl derivatives with heterocyclic nucleobase analogues such as pyrimidinones .…”