Synthesis of Nα-protected formamides from amino acids using MgO nano catalyst: Study of molecular docking and antibacterial activity

Abstract

Abstract. Green synthesis of nano MgO particles and their application in the formylationof isocyanates of N-Fmoc/Cbz/Boc protected amino acids were reported. Nano magnesium oxide catalysed reaction of isocyanate with 96% formic acid was established to obtain formamides. For this, the carboxyl group of protected amino acids was activated via mixed anhydride method and treated with NaN3. The formed azides were converted into their isocyanates through Curtius rearrangement and treated with HCOOH and catalytic amount of nano MgO. The advantages of this method were being remarkably simple and attaining economically low-cost nano metal oxide under milder reaction conditions. Most importantly, MgO could be easily separated and other basic impurities were removed through a simple work-up. This protocol showed high e ciency in catalysing the transformation in a greener fashion. The molecular docking study of the synthesized compounds was performed against the macromolecules sortase-A and glucosamine 6-phosphate synthase to understand the binding interactions. The results of in vitro antibacterial activities of the synthesized compounds were supported by docking analysis.

Evaluation of Fe-Mg Binary Oxide for As (III) Adsorption—Synthesis, Characterization and Kinetic Modelling

“…It is important to note that the peak observed at 598, which can be assigned to Fe–O–Fe stretching modes, has shifted to a higher frequency from 570 when mixed oxides of Fe-Mg are formed [ 39 , 41 , 42 , 43 , 44 ]. The bands that appeared at low frequencies of 860 and 441 cm −1 correspond to stretching vibrations of Mg–O–Mg bonding also shows a shift towards a higher frequency range, which corresponds with previously reported work [ 38 , 45 , 46 , 47 ]. These results indicate the formation of nano Fe-Mg mixed oxides.…”

Novel Nano-Fe2O3-Co3O4 Modified Dolomite and Its Use as Highly Efficient Catalyst in the Ozonation of Ammonium Solution

“…In the FTIR spectrum of activated dolomite (Figure 2(b)) appeared the band at 3448 cm -1 which was assigned to the vibration of OH groups [23]. In addition, the peak at 428 cm -1 is attributed to the stretching of Mg-O bonds [24]. In the FTIR spectrum of Fe 2 O 3 /dolomite (Figure 2(c)) appeared the bands at 548 and 638 cm -1 which are characteristic for Fe-O bonding [25,26].…”

Versatile Heterogeneous Catalytic System for the Selective Synthesis of Limonene Epoxide and Diepoxide

“…53,87 The band observed at 1480 cm −1 is assigned to the presence of −OH stretching due to the adsorption of water on the surface of the metal. 88 The bands appearing at low frequencies of 857 and 690 cm −1 are attributed to the stretching vibration of −Mg− O−Mg−O− bonding. 89,90 An additional slight band can be observed in the spectrum of the spent material, appearing at approximately 2920 cm −1 .…”