Synthesis of Optically Active Helical Poly(2-methoxystyrene). Enhancement of HeLa and Osteoblast Cell Growth on Optically Active Helical Poly(2-methoxystyrene) Surfaces

Gordon, Keith L.; Sannigrahi, Biswajit; McGeady, Paul; Wang, X. Q.; Mendenhall, Juana; Khan, Ishrat M.

doi:10.1163/156856208x399116

Cited by 13 publications

(15 citation statements)

References 45 publications

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“…On the other hand, the interfacial/surface energy becomes unfavorable. 53,54 Additionally, at a constant N C , as the N A increases, the phase transition experiences the progress of S A / C A / G A / L / G C . Originally, the volume fraction of A blocks was too low, so that C blocks were inclined to form the matrix and the S A , C A and G A phases are formed.…”

Section: Inuence Of Block Lengths and Gra Number On Phase Behaviormentioning

confidence: 99%

Phase behaviors of side chain liquid crystalline block copolymers

Huang

Jiang

et al. 2015

RSC Adv.

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The microphase separation of side chain liquid crystalline (SCLC) block copolymers was studied using dissipative particle dynamics (DPD) simulations. The block copolymer monomer consists of flexible A segments and flexible B segments grafted by rigid C side chains, where the A, B and C blocks are incompatible with each other. The phase structures of the SCLC copolymers were found to be controlled by A and C block lengths and the graft number. Various mesophases, such as spheres, cylinders, gyroids, and lamellae, were obtained. Phase stability regions in the space of C block length and A block length (or graft number and A block length) were constructed. The packing ordering of C side chains was also studied, and discovered to increase as the temperature decreases or the rigid C side chains increase. In addition, the results of the SCLC copolymers were compared with those of flexible copolymers and available experimental observations. The simulation results in the present work provide useful information for future investigations on SCLC copolymers.

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Section: Inuence Of Block Lengths and Gra Number On Phase Behaviormentioning

confidence: 99%

Phase behaviors of side chain liquid crystalline block copolymers

Huang

Jiang

et al. 2015

RSC Adv.

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“…This is usually achieved by utilizing steric congestion substituents, which restrict the free rotations around the σ-bonds linking main chain carbon atoms. ,, The attachment of large pendant groups to polymer main chain increases the internal rotation barrier and has led to numerous helical bulky poly(meth)acrylates and poly(meth)acrylamides. − Despite these remarkable successes, most of the efforts to obtain optically active helical polystyrene derivatives end with undesired results. Isotactic-rich poly(3-methyl-4-vinylpyridine), poly(2-methoxystyrene), and some polystyrenes bearing ortho -amino groups are capable of taking dominant helical conformations with an excess screw sense at low temperature but lose their optical activities quickly even at ambient temperature. − The helical conformations of vinylterphenyl polymers are stable because of high population of rod-like, laterally attached p -terphenyl pendants. − However, they can only be prepared by radical polymerization and are therefore endowed with disordered configurations. In addition, the p -terphenyl-based vinyl monomers demand multistep tedious synthetic procedures.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Stereospecific Polymerization of a Novel Bulky Styrene Derivative

Wang

Liu

et al. 2016

Macromolecules

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A novel vinylbiphenyl monomer, 2-methoxy-5-phenylstyrene (MOPS), was designed and efficiently synthesized to investigate the stereospecific polymerization of bulky and polar styrenic derivative. Regardless of its large side group and electron-donating o-methoxy substituent, this compound showed a high polymerizability and was readily converted to the corresponding polymers with moderate to high molecular mass through radical, anionic, and coordination polymerizations. The resultant polymers were characterized by a combination of 1H/13C NMR spectrometry, thermal analysis, and wide-angle X-ray diffraction. Radical polymerization initiated by AIBN in toluene at 60 °C produced a syndiotactic-rich (rr = 0.37) polymer as most bulky vinyl monomers, whereas anionic polymerizations induced by n-BuLi yielded only isotactic-rich polymers no matter if polar tetrahydrofuran (−78 °C, mm = 0.54) or apolar toluene (−40 °C, mm = 0.78) was employed as the solvent. The isotactic-rich microstructure obtained by anionic polymerization in polar solvent at low temperature, the condition that usually leads to syndiotactic-rich polymer, manifested the strong interactions between the o-methoxy groups of the growing chain end and the penultimate unit with the lithium counterion. Highly isotactic (mm = 0.95) and perfect syndiotactic (rr > 0.99) polymers were obtained via coordination polymerizations in toluene at ambient temperature with the β-diketiminatoyttrium precursor (I) and the heterocyclic-fused cyclopentadienylscandium complex (III) as the catalytic precursor, respectively. All the polymers were thermally stable with 5% weight loss temperatures above 360 °C. They underwent glass transitions in the temperature range of 124–140 °C depending on the tacticity, much higher than polystyrene, implying the dominant role of congestion effect of large side groups on the segment movement restriction of polymer chain. Both isotactic and syndiotactic polymers were crystalline and had melting points higher than 300 °C, although the atactic and less stereoregular polymers were amorphous. The facile synthesis in conjunction with stereostructure tailorability, high thermal stability, glass transition temperature, and melting point makes the polymer a promising candidate for not only helical functional material but also engineering plastics.

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“…Biofunctional polymers have been prepared with wide variety of applications ranging from diagnostics to therapeutics and tissue engineering [9][10][11][12][13]. An approach to synthesizing polymers with bioactive properties is directly attaching a bioactive moiety to the synthetic polymer.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block Copolymers

et al. 2014

Self Cite

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Biofunctional block copolymers are becoming increasingly attractive materials as active components in biosensors and other nanoscale electronic devices. We have described two different classes of block copolymers with biofuctional properties. Biofunctionality for block copolymers is achieved through functionalization with appropriate biospecific ligands. We have synthesized block copolymers of electroactive poly(3-decylthiophene) and 2-hydroxyethyl methacrylate by atom transfer radical polymerization. The block copolymers were functionalized with the dinitrophenyl (DNP) groups, which are capable of binding to Immunoglobulin E (IgE) on cell surfaces. The block copolymers were shown to be redox active. Additionally, the triblock copolymer of α, ω-bi-biotin (poly(ethylene oxide)-b-poly (styrene)-b-poly(ethylene oxide)) was also synthesized to study their capacity to bind fluorescently tagged avidin. The surface-active property of the poly(ethylene oxide) block improved the availability of the biotin functional groups on the polymer surfaces. Fluorescence microscopy observations confirm the specific binding of biotin with avidin.

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Synthesis of Optically Active Helical Poly(2-methoxystyrene). Enhancement of HeLa and Osteoblast Cell Growth on Optically Active Helical Poly(2-methoxystyrene) Surfaces

Cited by 13 publications

References 45 publications

Phase behaviors of side chain liquid crystalline block copolymers

Phase behaviors of side chain liquid crystalline block copolymers

Synthesis and Stereospecific Polymerization of a Novel Bulky Styrene Derivative

Fabrication of Bioactive Surfaces by Functionalization of Electroactive and Surface-Active Block Copolymers

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