Synthesis of Oxa-bridged Medium-Sized Carbocyclic Rings

Abstract

Natural products with oxa-bridged medium-sized carbocyclic ring structure units play an important role in nature. Therefore, developing novel and efficient methods is essential for synthesizing complex natural products containing oxygen-bridged rings. In this article, pro-gress toward the synthesis of oxygen-bridged seven and eight-membered rings is reviewed in terms of the strategies employed.