Synthesis of oxidized sodium alginate and its electrospun bio-hybrids with zinc oxide nanoparticles to promote wound healing

Wang, Wei; Liu, Mingyue; Shafiq, Muhammad; Li, Haiyan; Hashim, Rashida; El‐Newehy, Mohamed H.; El‐Hamshary, Hany; Morsi, Yosry; Mo, Xiumei

doi:10.1016/j.ijbiomac.2023.123480

Cited by 27 publications

(4 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the FTIR spectrum of SA, the broad absorption peak at 3445 cm −1 corresponds to hydroxyl (‐OH) stretching vibration peak of SA, while the peaks at 1456 and 1619 cm −1 represent the symmetric and antisymmetric stretching peaks of the carboxyl group in SA. The spectrum of OSA, when compared to SA, exhibited a new characteristic absorption peak at 1699 cm −1 , which corresponds to the telescopic vibration peak of the aldehyde group, indicating the successful preparation of sodium di‐formal alginate 29 . In the FTIR spectrum of CMS, the absorption peak at 1588 cm −1 was generated by the overlap of the bending vibration peak of the amino group and the asymmetric stretching vibration peak of the carboxy group in carboxymethyl chitosan.…”

Section: Resultsmentioning

confidence: 96%

“…The spectrum of OSA, when compared to SA, exhibited a new characteristic absorption peak at 1699 cm À1 , which corresponds to the telescopic vibration peak of the aldehyde group, indicating the successful preparation of sodium di-formal alginate. 29 In the FTIR spectrum of CMS, the absorption peak at 1588 cm À1 was generated by the overlap of the bending vibration peak of the amino group and the asymmetric stretching vibration peak of the carboxy group in carboxymethyl chitosan. The symmetric stretching vibration peak of the carboxyl group ( COO ) in carboxymethyl chitosan was observed at 1407 cm À1 , while a wider characteristic peak at 3421 cm À1 was caused by the partial overlap of the amino group ( NH 2 ) and the hydroxyl group ( OH).…”

Section: Infrared Spectral Analysismentioning

confidence: 99%

See 1 more Smart Citation

Construction of carboxymethyl chitosan @ sodium oxide alginate aerogel for efficient adsorption of malachite green

Li,

Zhang,

Guo

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

Water pollution has emerged as a formidable issue of utmost concern in the world, and the design of three‐dimensional porous, high adsorption performance, and sustainable adsorbent materials is of great significance for wastewater purification. Naturally abundant sodium alginate was used to prepare oxidized sodium alginate (OSA), a biomass macromolecule containing an aldehyde group. A double network interpenetrating structure based on carboxymethyl chitosan (CMS) and OSA was constructed without any small molecule cross‐linking agent throughout, and a Schiff base reaction occurred at room temperature to prepare chemically stable CMS@OSA aerogels, which contain a continuous and dense porous structure inside the aerogel. CMS and OSA both contain an anionic reactive group, carboxyl, which makes them both matrix and functional materials, enabling selective adsorption of malachite green (MG) dyes. The prepared aerogel adsorbent showed a high adsorption capacity (302 mg/g) for MG at room temperature. The adsorption mechanism between the aerogel adsorbent and the adsorbent mass was investigated, and the effect of different factors on the adsorption performance was analyzed. The fitting coefficients of both the adsorption kinetic model and the isotherm model reached 0.99. The ingenious preparation method and excellent adsorption performance offer great prospects for chitosan biomass aerogels to play a role in environmental protection and economy.Highlights An interpenetrating structure based on the Schiff base reaction. Construction of three‐dimensional porous structures. Pure ecological raw materials without toxic crosslinkers. High adsorption capacity at 302 mg/g for malachite green.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Infrared Spectral Analysismentioning

confidence: 99%

Construction of carboxymethyl chitosan @ sodium oxide alginate aerogel for efficient adsorption of malachite green

Li,

Zhang,

Guo

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

show abstract

“…100,101 However, the nonspinnable nature of SA limits its application. Wang et al 102 improved the spinnability by oxidizing sodium alginate (OSA). Meanwhile, OSA was combined with zinc oxide nanoparticles (ZnO-NPs) to create composite fiber membranes.…”

Section: Electrospinning Wound Dressing Using Polysaccharide Polymersmentioning

confidence: 99%

Advances in wound dressing based on electrospinning nanofibers

Zhang,

Wang,

Gao

et al. 2023

J of Applied Polymer Sci

View full text Add to dashboard Cite

In recent years, there has been a significant focus on bioactive dressings suitable for treating chronic and acute wounds. Electrospinning nanofibers are considered advanced dressing options due to their high porosity and permeability to air and water, effective barrier properties against external pathogens, and excellent resemblance to the extracellular matrix for wound healing and skin regeneration. This article reviews the recent advancements in the application of electrospinning nanofibers for bioactive wound healing. The review begins with an overview of the wound healing process and electrospinning methods. It then explores the advantages and disadvantages of different synthetic and natural polymers used in the preparation of electrospinning wound dressings. The natural polymers discussed in this review include collagen, gelatin, silk fibroin, chitosan, hyaluronic acid, and sodium alginate. Additionally, the review delves into commonly used synthetic polymers like polyvinyl alcohol, polyvinyl chloride, polyethylene lactone, polylactide, and polyurethane for wound dressing applications. Furthermore, the review examines the blending of natural and synthetic polymers to create high‐performance wound dressings. It also explores the incorporation of functional additives, such as antimicrobial agents, growth factors, and natural extracts, into electrospinning nanofibers to expedite wound healing and tissue repair. In conclusion, electrospinning is an emerging technology that provides unique opportunities for designing more effective wound dressings and care products.

show abstract

“…Composite hydrogel/NF architectures can be achieved by combining 3D printing and electrospinning technologies [28]. Reported designs involved NF interleaves between printed layers [29], composite core/shell fiber scaffolds [30,31] or hydrogels incorporating short NFs [32].…”

Section: Introductionmentioning

confidence: 99%

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing

Metwally,

El-Habashy,

El-Hosseiny

et al. 2023

Biofabrication

View full text Add to dashboard Cite

There is a constant demand for novel materials/biomedical devices to accelerate the healing of hard-to-heal wounds. Herein, an innovative 3D-printed bioinspired construct was developed as an antibacterial/regenerative scaffold for diabetic wound healing. Hyaluronic/chitosan (HA/CS) ink was used to fabricate a bilayer scaffold comprising a dense plain hydrogel layer topping an antibacterial/regenerative nanofibrous layer obtained by incorporating the hydrogel with polylactic acid nanofibrous microspheres (MS). These were embedded with nano ZnO (ZNP) or didecyldimethylammonium bromide (DDAB)-treated ZNP (D-ZNP) to generate the antibacterial/healing nano/micro hybrid biomaterials, Z-MS@scaffold and DZ-MS@scaffold. Plain and composite scaffolds incorporating blank MS (blank MS@scaffold) or MS-free ZNP@scaffold and D-ZNP@scaffold were used for comparison. 3D printed bilayer constructs with customizable porosity were obtained as verified by SEM. The DZ-MS@scaffold exhibited the largest total pore area as well as the highest water-uptake capacity and in vitro antibacterial activity. Treatment of Staphylococcus aureus-infected full thickness diabetic wounds in rats indicated superiority of DZ-MS@scaffold as evidenced by multiple assessments. The scaffold afforded 95% wound-closure, infection suppression, effective regulation of healing-associated biomarkers as well as regeneration of skin structure in 14 d. On the other hand, healing of non-diabetic acute wounds was effectively accelerated by the simpler less porous Z-MS@scaffold. Information is provided for the first-time on the 3D printing of nanofibrous scaffolds using non-electrospun injectable bioactive nano/micro particulate constructs, an innovative ZNP-functionalized 3D-printed formulation and the distinct bioactivity of D-ZNP as a powerful antibacterial/wound healing promotor. In addition, findings underscored the crucial role of nanofibrous-MS carrier in enhancing the physicochemical, antibacterial, and wound regenerative properties of DDAB-nano ZnO. In conclusion, innovative 3D-printed DZ-MS@scaffold merging the MS-boosted multiple functionalities of ZNP and DDAB, the structural characteristics of nanofibrous MS in addition to those of the 3D-printed bilayer scaffold, provide a versatile bioactive material platform for diabetic wound healing and other biomedical applications.

show abstract

Synthesis of oxidized sodium alginate and its electrospun bio-hybrids with zinc oxide nanoparticles to promote wound healing

Cited by 27 publications

References 83 publications

Construction of carboxymethyl chitosan @ sodium oxide alginate aerogel for efficient adsorption of malachite green

Construction of carboxymethyl chitosan @ sodium oxide alginate aerogel for efficient adsorption of malachite green

Advances in wound dressing based on electrospinning nanofibers

Bioinspired 3D-printed scaffold embedding DDAB-nano ZnO/nanofibrous microspheres for regenerative diabetic wound healing

Contact Info

Product

Resources

About