Synthesis of oxime bearing cyclophosphazenes and their reactions with alkyl and acyl halides

Cil, Erol; Arslan, Mustafa; Görgülü, Ahmet Orhan

doi:10.1002/hc.20176

Cited by 12 publications

(2 citation statements)

References 31 publications

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“…The synthesis of different phosphazene compounds has been reported [13,[45][46][47][48][49][50][51][52][53] but there are only four articles about synthesis of the phosphazene compounds bearing chalcone groups [10,[54][55][56], there are, however, no studies about synthesis of dioxybiphenyl substituted chalcone-cyclophosphazene compounds. The cyclotriphosphazenes bearing 2,2 0 -dihydroxybiphenyl are much more stable to hydrolysis and thermal decomposition than hexachlorocyclotriphosphazene [1].…”

Section: G R a P H I C A L Abstractmentioning

confidence: 96%

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Görgülü

Koran

Özen

et al. 2015

Journal of Molecular Structure

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Section: G R a P H I C A L Abstractmentioning

confidence: 96%

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Görgülü

Koran

Özen

et al. 2015

Journal of Molecular Structure

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“…There are also a large number of literature reports on reactions of the functional groups on phosphazene substituents [10,30]. Typical of these include coupling reactions of trimeric phosphazene azides with aryloxy, alkoxy, and dialkylamino cosubstituents [31], N-vinylic phosphazenes with azodicarboxylic and acetylenic esters [32], oxime-phosphazene derivatives with alkyl and acyl substituents [33,34], polymers from 4-formylphenoxy [35,36], maleic [37], and 3,4-methylenedioxyphenoxy substituents [38], and oxime-bearing hexakis(4-formylphenoxy)phosphazene and derivatives [33,34,39].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of oxime‐bearing hexakis(2‐formylphenoxy)‐phosphazene and its derivatives

Pamukçi

Cil

Begeç

et al. 2007

Heteroatom Chemistry

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Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

Cil¹,

Tanyildizi²,

Özen³

et al. 2012

Archiv der Pharmazie

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A new spirocyclophosphazene, 2,2-bis(2-formylphenoxy)-4,4,6,6-bis[spiro(2',2″-dioxy-1'-1″-biphenylyl)]cyclotriphosphazene (3), was obtained from the reaction of 2,2-dichloro-4,4,6,6-bis[spiro(2',2″-dioxy-1'-1″-biphenylyl)]cyclotriphosphazene (2) with 2-hydroxybenzaldehyde. New phosphazene derivatives bearing Schiff base and dioxybiphenyl groups have been synthesized by the reactions of 3 with different amines. The structures of the compounds were defined by elemental analysis, IR, (1) H, (13) C, and (31) P NMR spectroscopy. All the synthesized compounds were screened for their antibacterial activity against both types of Gram-negative and Gram-positive bacteria. The most potent antibacterial compound of this series was compound 12 which has the low MIC value of 3.75-0.9375 µg/mL. Both minimal inhibitory concentrations (MIC) and inhibition zones were determined in order to monitor the efficacy of the synthesized compounds. New compounds were also screened for anticonvulsant, CNS depressant, and sedative-hypnotic activity. After i.p. injection to mice at doses of 30, 100, and 300 mg/kg body weight phosphazenes were examined in the maximal electroshock-induced seizure (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. Compounds 4, 5, and 11 were found to be active in both MES screen and scPTZ screen at 0.5 h. All except 12 showed more than 44% decrease in locomotor activity after 1 h of compound administration via actophotometer screen. CNS-depressant activity screened with the help of the forced swim method resulted in some potent compounds. Except for 7 and 12 other tested compounds were found to exhibit potent CNS depressants activity as indicated by increased immobility time.

show abstract

Synthesis of oxime bearing cyclophosphazenes and their reactions with alkyl and acyl halides

Abstract: Two novel cyclophosphazenes containing oxime groups were prepared from the hexakis

Cited by 12 publications

References 31 publications

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Synthesis, structural characterization and anti-carcinogenic activity of new cyclotriphosphazenes containing dioxybiphenyl and chalcone groups

Synthesis and characterization of oxime‐bearing hexakis(2‐formylphenoxy)‐phosphazene and its derivatives

Synthesis, Characterization, and Biological–Pharmacological Evaluation of New Phosphazenes Bearing Dioxybiphenyl and Schiff Base Groups

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