Synthesis of Oxorhenium(V) Complexes Derived from 7α-Functionalized Testosterone: First Rhenium-Containing Testosterone Derivatives

Potential Technetium Small Molecule Radiopharmaceuticals

“…50−65% to endocrine therapy. Prostate cancer has been found to be responsive to both androgens and estrogens and contains androgen receptors, although their levels are relatively low. , Targeting the steroid receptors with 99m Tc complexes has been the focus of several research groups and has proven quite challenging. Steroids are relatively small molecules (MW ca.…”

“…Johannsen and co-workers have extended their 3 + 1 ligand system for Tc and Re to target the estrogen and androgen receptors. , Dithiol−thioether and dithiol tridentate ligands and monodentate thiol-derivatized estradiols (on the A ring) were used to prepare model Re(V) oxo complexes for targeting the estrogen receptor (Figure c) . No stability data, in vitro receptor binding data, or in vivo biodistribution data are reported.…”

Luminescent rhenium fac-tricarbonyl-containing complexes of androgenic oxo-steroids

“…Some examples of rhenium-containing androgen derivatives have been reported; Wüst et al prepared such complexes by funtionalising testosterone at the 7α-position with thiol-containing ligands capable of coordinating an oxorhenium centre. 15 Jaouen and co-workers have synthesised a range of CpRe(CO) 3 -substituted complexes of cholest-4-en-3-one, 16 and latterly of testosterone and DHT. 17 Transition metal complexes containing ligands with a 3,3′diamino-2,2′-bipyridyl core have been shown previously to react readily with ketones 18 and aldehydes 19 to form seven-membered cyclic aminal products and therefore this chemistry was utilised in this study.…”

Steroid Conjugates as Potential Anti-Cancer Agents

“…В работах других исследователей синтезированы конъюгаты тестостерона, содержащие комплексы Re (V) и радиоактивного 99 Tc, а также конъюгаты эстра диола, содержащие комплексы Pd, Ni и Zn 62-68 (рис. 7) [67][68][69].…”