Synthesis of Oxygen- or Nitrogen-Containing Heterocyclic Compounds via Radical Addition Cascade Cyclization

Abstract

Oxygen-or nitrogen-containing heterocyclic compounds have been widely applied in pharmaceuticals, chemical products and materials, and the synthesis of these compounds has drawn much attention. One of the convenient and efficient strategies for the construction of various oxygen-or nitrogen-containing heterocycles is radical addition cascade cyclization in recent years. This article offers an overview on the radical addition cascade cyclization strategies based on the types of oxygenor nitrogen-containing heterocyclic compounds.

Visible Light-Induced Radical Addition/Annulation to Construct Phenylsulfonyl-Functionalized Dihydrobenzofurans Involving an Intramolecular 1,5-Hydrogen Atom Transfer Process

“…Radical addition/cyclization cascade reactions provide an excellent strategy for the synthesis of various functionalized heterocycles . The radical-mediated intramolecular hydrogen atom transfer (HAT), as a highly regioselective and mild approach to the functionalization of remote C­(sp 3 )–H bonds, offers a special opportunity in the assembly of cyclic scaffolds .…”