Synthesis of P- and S-Stereogenic Compounds via Enantioselective C–H Functionalization

Abstract

Transition metal-catalyzed enantioselective C−H functionalization has emerged as an efficient and powerful strategy to access various chiral molecules. Recently, this strategy also provided a complementary pathway to the construction of P- and S-stereogenic compounds. In this short review, we summarize the development and applications of various catalytic systems, including Pd(II)/MPAA, Pd(0)/trivalent phosphorus chiral ligand, chiral CpxM(III) (M = Rh, Ir), half-sandwich d6 Ir(III) and Ru(II) with chiral carboxylic acid (CCA) ligand, Ir(I)/chiral bidentate boryl ligand, and Ir(I)/chiral cation, in the access of these chiral compounds via enantioselective C−H functionalization.

Transition-metal-catalyzed atroposelective synthesis of axially chiral styrenes

“…In the past few decades, directed transition-metal-catalyzed asymmetric C–H functionalization has been dramatically developed, 25 bringing a powerful method for synthesizing structurally complicated chiral molecules. 26 For the construction of C(vinyl)–C(aryl) axes, the C–H activation process via dynamic kinetic resolution is always the enantio-determining step. Several palladium( ii )-catalyzed enantioselective olefinations, alkynylations and arylations have been developed using this strategy.…”

Advances and Challenges in Photoelectrochemical Redox Batteries for Solar Energy Conversion and Storage

“…Typically, the membranes used in the redox battery can be classified into two categories: that is ion exchange membranes and non‐ionic porous membranes. [ 22c,73 ] The ion exchange membranes, however, have received more applications in the redox batteries. Hence, recent research investigations focusing on these kind of membranes are summarized in this section by using the conventional all‐vanadium redox batteries as the reference case.…”

Copper-Catalyzed Sulfonylation Reaction of NH-Sulfoximines with Aryldiazonium Tetrafluoroborates and Sulfur Dioxide: Formation of N-Sulfonyl Sulfoximines

“…Sulfoximines, an important organosulfur compound, is a special structural unit existing in a variety of pharmaceutical molecules, agrochemicals, and bioactive natural products (Scheme ), exhibiting many unique properties, such as good water solubility, chemical and biological importance, and excellent oriented coordination ability . In the chemistry of sulfoximine derivatives, N–H bond functionalization represents an efficient and robust synthetic strategy toward modified scaffolds .…”