2020
DOI: 10.1021/acs.jchemed.0c00325
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Synthesis of PCL–PEG–PCL Triblock Copolymer via Organocatalytic Ring-Opening Polymerization and Its Application as an Injectable Hydrogel—An Interdisciplinary Learning Trial

Abstract: Biocompatible and biodegradable block copolymers composed of poly­(ethylene glycol) (PEG) and aliphatic polyester are a class of promising biomaterials. Herein, a teaching experiment was designed to furnish undergraduates with a reliable method to synthesize an amphiphilic poly­(ε-caprolactone)-PEG-poly­(ε-caprolactone) (PCL–PEG–PCL) triblock copolymer via ring-opening polymerization of ε-caprolactone using PEG as the macroinitiator and diphenyl phosphate as the green organocatalyst; the concentrated solution … Show more

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Cited by 25 publications
(32 citation statements)
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“…In the cooling curves, the broad exothermic peaks at around −15 to 10 °C appeared, which reflected the crystallization transitions of the copolymers. For thermosensitive PCL–PEG–PCL triblock copolymers with similar MWs, the melting transitions and crystallization transitions of PCL blocks usually locate at 40–60 °C and 10–35 °C, respectively. ,, The random copolymerization of a small amount of 5-alkyl δ-lactones bearing various side groups noticeably hinders the crystallization of PCL domain, resulting in significant decreases both in the T m and crystallization temperature ( T c ) of the polyester blocks.…”
Section: Resultsmentioning
confidence: 99%
“…In the cooling curves, the broad exothermic peaks at around −15 to 10 °C appeared, which reflected the crystallization transitions of the copolymers. For thermosensitive PCL–PEG–PCL triblock copolymers with similar MWs, the melting transitions and crystallization transitions of PCL blocks usually locate at 40–60 °C and 10–35 °C, respectively. ,, The random copolymerization of a small amount of 5-alkyl δ-lactones bearing various side groups noticeably hinders the crystallization of PCL domain, resulting in significant decreases both in the T m and crystallization temperature ( T c ) of the polyester blocks.…”
Section: Resultsmentioning
confidence: 99%
“…Sol-Gel and Gel-Sol (Suspension) Transitions with Temperature: Test-tube inversion method was used to investigate the transition temperatures of copolymer aqueous solutions. [95,96] First, copolymer solutions were made with different ratios of copolymer-1/copolymer-2 (1:0, 2:1, 1:1, 1:2, 0:1). Second, 0.5 mL of each polymer aqueous solution was put into a small vial.…”
Section: Methodsmentioning
confidence: 99%
“…[ 84 ] Most of biodegradable polyesters such as PLA and their copolymers are obtained via ring opening of cyclic esters assisted by Sn(Oct) 2 and ROH. [ 85‐88 ] The underlying mechanism of the coordination‐insertion ROP of LA in presence of Sn(Oct) 2 and ROH is thus much required to be explored. The present research deepens the microscopic understanding of the polymerization process of lactide.…”
Section: Discussionmentioning
confidence: 99%