Synthesis of PEGylated Semiconducting Polymer Amphiphiles for Molecular Photoacoustic Imaging and Guided Therapy

Xie, Chen; Cheng, Penghui; Pu, Kanyi

doi:10.1002/chem.201705716

Cited by 20 publications

(15 citation statements)

References 90 publications

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“…The publications and citations about organic semiconducting agents are increasing in number, and there are some reviews nicely summarizing their syntheses, optical properties, and general sensing applications . This review instead focuses on the recent progress on the development of organic semiconducting agents for deep‐tissue molecular imaging including NIR‐II fluorescence, self‐luminescence, and PA imaging, and highlights the chemistry and imaging mechanisms toward biological applications ( Tables , 2 and 3 ).…”

Section: Introductionmentioning

confidence: 99%

Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

2018

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Optical imaging has played a pivotal role in biology and medicine, but it faces challenges of relatively low tissue penetration and poor signal-to-background ratio due to light scattering and tissue autofluorescence. To overcome these issues, second near-infrared fluorescence, self-luminescence, and photoacoustic imaging have recently emerged, which utilize an optical region with reduced light-tissue interactions, eliminate real-time light excitation, and detect acoustic signals with negligible attenuation, respectively. Because there are only a few endogenous molecules absorbing or emitting above the visible region, development of contrast agents is essential for those deep-tissue optical imaging modalities. Organic semiconducting agents with π-conjugated frameworks can be synthesized to meet different optical imaging requirements due to their easy chemical modification and legible structure-property relation. Herein, the deep-tissue optical imaging applications of organic semiconducting agents including small-molecule agents and nanoparticle derivatives are summarized. In particular, the molecular engineering and nanoformulation approaches to further improve the tissue penetration and detection sensitivity of these optical imaging modalities are highlighted. Finally, current challenges and potential opportunities in this emerging subfield of biomedical imaging are discussed.

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Section: Introductionmentioning

confidence: 99%

Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

2018

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“…For example, surface conjugation of hydrophilic poly(ethylene glycol) (PEG) is the most popular strategy to achieve immune escape and extended half‐lives. [ 19–25 ] Notwithstanding the previously supposed inertness, accelerated blood clearance has been observed from PEGylated synthetic nanoparticles. [ 26,27 ] Additionally, the concerns on the biocompatibility of synthetic materials have not as yet been eliminated.…”

Section: Introductionmentioning

confidence: 99%

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

Zeng

2020

Adv Funct Materials

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144

103

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Cancer immunotherapy has received tremendous attention in the past decade owing to its clinical successes with the use of immune-checkpoint inhibition and chimeric antigen receptor T cell therapy. However, only a small proportion of the patients have benefited from these immunotherapeutic drugs, which has raised concerns about the low response rate and immune-related adverse events. Nanomedicines have served as a paradigm for preferential tumor accumulation but still confront issues such as poor circulation and insufficient tumor accumulation. By virtue of coating nanoparticles with cell membranes from diverse cell sources, active proteins on cell membranes can impart a variety of desired functionalities or supplementary therapeutic effects to nanoparticles, providing ways for enhanced cancer immunotherapy. In this review, the recent advances of cell membrane camouflaged nanoparticles applied to the improved immunotherapy are discussed on the basis of different sources of cell membranes and corresponding working mechanisms. These biomimetic nanoparticles can potentially deliver therapeutic agents to the designated sites and actively engage in particular stages of the cancer immunity cycle, eliciting antitumor immunity with less off-target toxicities.

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“…Presently, theranostic agents with strong optical absorption in the near-infrared (NIR) biological window (700 - 1100 nm) have been extensively developed due to their deep tissue penetration and minimal photodamage to biological tissues 21 including inorganic 22-26 and organic nanomaterials 27-30. Compared to inorganic nanomaterials, organic nanoagents have exhibited numerous advantages such as excellent biocompatibility, tunable chemical structures, and potential biodegradability 31, 32.…”

Section: Introductionmentioning

confidence: 99%

Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics

Gao¹,

Zhang

Liu³

et al. 2019

Theranostics

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Background : Engineering a single organic-molecule-based nanoparticle integrating precise diagnosis and effective therapy is of great significance for cancer treatment and future clinical applications but remains a great challenge. The goal of this study is to explore small organic molecule-based nanoparticles with high photothermal conversion efficiency for photoacoustic imaging-guided therapy. Methods : Heptacyclic B, O-chelated BODIPY structure (namely Boca-BODIPY) with strong near-infrared (NIR) absorption was designed as a theranostic agent through simply molecular engineering, in which heavy atoms and alkyl chains were introduced to promote its application for tumor theranostics. The Boca-BODIPY molecules are further encapsulated in reduced bovine serum albumin (BSA) through self-assembly. Results : The BSA-Boca-BODIPY exhibited excellent biocompatibility, extraordinary stability and high photothermal conversion efficiency up to 58.7%. The nanoparticles could dramatically enhance photoacoustic contrast of the tumor region, and the signal-to-noise ratio was increased about 14 times at 10 h post intravenous injection in 4T1 tumor-bearing mice. In addition, the nanoassemblies can efficiently convert laser energy (808 nm, 0.75 w cm -2 , 5min) into hyperthermia for tumor ablation. Under the photoacoustic imaging-guided photothermal therapy (PTT), the 4T1 cancer cells were efficiently killed, no tumor recurrence and PTT-induced toxicity is observed. Conclusions : Molecular engineering is a promising way to design organic-molecule-based nanoparticles for cancer theranostics. Other organic-molecule-based nanoparticles which show great promise for imaging-guided cancer precision therapy can be engineered through this method.

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Synthesis of PEGylated Semiconducting Polymer Amphiphiles for Molecular Photoacoustic Imaging and Guided Therapy

Cited by 20 publications

References 90 publications

Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics

Improving Cancer Immunotherapy by Cell Membrane‐Camouflaged Nanoparticles

Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics

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