Synthesis of peppermint oil-loaded chitosan/alginate polyelectrolyte complexes and study of their antibacterial activity

Deka, Chayanika; Deka, Deepanwita; Bora, Montu Moni; Jha, Dhruva Kumar; Kakati, Dilip Kumar

doi:10.1016/j.jddst.2016.08.007

Cited by 38 publications

(15 citation statements)

References 15 publications

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“…The controlled bactericide release systems developed to date include plastic films, ,, wafers, , beads, and a diverse array of micro- and nanoparticles, ,, fibers, , coatings, ,, and gels, − all of which have been used for encapsulating and slowly releasing biocidal small molecules. Among these sustained release vehicles are materials prepared through polyelectrolyte self-assembly. ,− These biocide-eluting materials have been prepared through two general approaches: (1) preparation of polyelectrolyte complex multilayers (PEMs), where tens of alternating layers of anionic and cationic polyelectrolyte layers were deposited on surfaces ,− and (2) complex coacervation, where complexes between a polyelectrolyte and an oppositely charged polymer, , protein, , or multivalent ions , were formed by simply mixing the two associating solutes in aqueous solution. In recent years, PEMs have been shown to provide antibacterial and antifungal activity over multiweek and multimonth timescales. , To our knowledge, however, despite their much simpler preparation, such long-term antibacterial activity has not been demonstrated for complex coacervates.…”

Section: Introductionmentioning

confidence: 99%

“…Building on these findings, here we investigate the use of PAH/TPP coacervates for the highly sustained release of antibacterial agents, with the view of developing products for sustained household, institutional, and (eventually) medical disinfectione.g., where the bactericide-eluting PAH/TPP coacervates are attached to (or incorporated within) wet surfaces or devices, ranging from the insides of showerheads to infection-prone surgical implants. Further, by using a hydrophobic, sparingly soluble molecule, Triclosan (TC; Scheme c) , as the model bactericide, we, for the first time, characterize the multifunctional PAH/TPP coacervates as materials for the long-term release of hydrophobic payloads, whichdespite being often encapsulated in biopolymeric (e.g., gelatin/anionic polysaccharide) coacervates ,− ,, have not yet been used with the PAH/TPP system.…”

Section: Introductionmentioning

confidence: 99%

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Highly Sustained Release of Bactericides from Complex Coacervates

Alam

Seo

Lapitsky

2020

ACS Appl. Bio Mater.

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Materials for preventing harmful bacterial contamination attract widespread interest in areas that include healthcare, home/personal care products, and crop protection. One approach to achieving this functionality is through the sustained release of antibacterial compounds. To this end, we show how putty-like complex coacervates, formed through the association of poly(allylamine hydrochloride) (PAH) with pentavalent tripolyphosphate (TPP) ions, can provide a sustained antibacterial effect by slowly releasing bactericides. Using triclosan (TC) as a model bactericide, we demonstrate that, through their dispersion in the parent PAH solution with nonionic surfactants, hydrophobic biocides can be efficiently and predictably encapsulated within PAH/TPP coacervates. Once encapsulated, the bactericide can be released over multiple months, and the release rates can be readily tuned by varying the bactericide and surfactant compositions used during encapsulation. Through this release, the PAH/TPP coacervates provide sustained bactericidal activity against model Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Escherichia coli) grown under a nutrient-rich condition over at least two weeks. Thereafter, though some partial activity persists after one month, the release slows down and the bactericide-eluting coacervates lose their efficacy. Overall, we show that bactericide release from easy-to-prepare complex coacervates can provide a pathway to sustained disinfection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly Sustained Release of Bactericides from Complex Coacervates

Alam

Seo

Lapitsky

2020

ACS Appl. Bio Mater.

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“…Moreover, alginate can be used in the manufacture of soft capsules and consumed as a beverage to lower blood sugar levels [18]. The use of sodium alginate or composite matrix with sodium alginate as an antibacterial material has been previously studied [19,20,21]. Because of its low toxicity, as well as its biocompatibility and biodegradability properties, sodium alginate is often applied when preparing biomedical materials, (e.g., wound dressing materials with antibacterial activity) [18,19].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity, Bactericidal, and Antioxidant Activity of Sodium Alginate Hydrosols Treated with Direct Electric Current

Król

Marycz

Kulig

et al. 2017

IJMS

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The aim of the study was to investigate the effect of using direct electric current (DC) of 0, 200, and 400 mA for five minutes on the physiochemical properties, cytotoxicity, antibacterial, and antioxidant activity of sodium alginate hydrosols with different sodium chloride concentrations. The pH, oxidation-reduction potential (ORP), electrical conductivity (EC), and available chlorine concentration (ACC) were measured. The effect of sodium alginate hydrosols treated with DC on Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, Micrococcus luteus, Escherichia coli, Salmonella enteritidis, Yersinia enterocolitica, Pseudomonas fluorescence, and RAW 264.7 and L929 cells was investigated. Subsequently, the antioxidant properties of hydrosols were evaluated by determining the scavenging ability of 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH) and ferric reducing antioxidant power (FRAP). The results have shown that after applying 400 mA in hydrosol samples with 0.1% and 0.2% NaCl all tested bacteria were inactivated. The ACC concentration of C400 samples with NaCl was equal to 13.95 and 19.71 mg/L, respectively. The cytotoxicity analysis revealed that optimized electric field conditions and the addition of sodium chloride allow for the avoidance of toxicity effects on normal cells without disturbing the antibacterial effects. Due to the presence of oxidizing substances, the DPPH of variants treated with DC was lower than the DPPH of control samples.

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“…In terms of encapsulation efficiency, some authors reported quite the same ranges, i.e. 78.2 to 83.4% [15] and 72.3 -89.7% [18] for mint oil, and 76.2 -83.7% for cardamom [12].…”

Section: Encapsulate Powder Yieldmentioning

confidence: 99%

“…The shifted to the lower melting temperature might be attributed by the interaction of PEG and mint oil. Mint oil might play a role as a plasticizer resulted in changes in the crystallization properties of encapsulating matrix [18]. The presence of essential oil could inhibit the crystallization of PEG upon fast cooling, leading to the formation of more amorphous state [13].…”

Section: Microstructurementioning

confidence: 99%

Polymeric Encapsulation of Mint Oil: Effect of Oil Load on the Physical Properties

Yuliani

Wahyuningsih

Widayanti

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Mint oil has many applications including foods, perfumes and fragrances, pharmaceuticals, cosmetics and pest control. This essential oil is easily damaged because of its high sensitivity to environmental conditions such as heat, oxygen, light and reactions with other compounds. Encapsulation provides protection of the oil against these undesirable conditions. This study was aimed at evaluating the characteristics of mint oil encapsulated in polyethylene glycol (PEG 6000) as influenced by mint oil load. Mint oil was encapsulated in polyethylene glycol at four different percentages (5.0, 7.5, 10 and 12.5%) using a melt dispersion technique. The experiment was done in two replicates. The encapsulates were characterized for their morphology, size attributes and thermal properties. Particulate sizes ranged from 281.4 – 569.5 nm and tended to increase with the increase in oil load. Microstructure of the particles examined under scanning electron microscope showed irregular flakes with sizes around 10 μm. These particles contained oil droplets in the sizes of about 200 – 500 nm as confirmed by observation with a transmission electron microscope. The enthalpy of melting of encapsulates were higher than that of mint oil, describing the enhancement of oil stability under thermal conditions. This study provides useful information in developing essential oil encapsulation for use in wider applications.

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Synthesis of peppermint oil-loaded chitosan/alginate polyelectrolyte complexes and study of their antibacterial activity

Cited by 38 publications

References 15 publications

Highly Sustained Release of Bactericides from Complex Coacervates

Highly Sustained Release of Bactericides from Complex Coacervates

Cytotoxicity, Bactericidal, and Antioxidant Activity of Sodium Alginate Hydrosols Treated with Direct Electric Current

Polymeric Encapsulation of Mint Oil: Effect of Oil Load on the Physical Properties

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