Synthesis of pH-responsive polymers forming recyclable aqueous two-phase systems and application to the extraction of demeclocycline

Gai, Zhiliang; Wan, Jiamin; Cao, Xuejun

doi:10.1016/j.bej.2018.08.016

Cited by 17 publications

(3 citation statements)

References 27 publications

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“…When HCl or NaOH was added to the ATPS, the change of pH affected the hydrophilicity and hydrophobicity of the pH-responsive PADB4.78 [13]. The pH was too low to form ATPS.…”

Section: Effect Of Phmentioning

confidence: 99%

“…Traditional ATPS are composed of polymer, salt, organic solvent, inorganic salt, and ionic liquid [8][9][10][11], these phase components are difficult to reuse. In order to solve above problems, some polymers responsive to light, temperature and pH have been synthesized in our laboratory, which can be conveniently recycled by adjusting environmental factors and used to construct novel recyclable ATPS [12][13][14]. Yang, T et al [15] synthesized pH-responsive polymer (PMDB3.36 and PADB4.05), both of which recovery were above 95%.…”

Section: Introductionmentioning

confidence: 99%

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Partition of Tea Saponin with a Novel Recyclable Thermo-pH Aqueous Two-Phase Systems

Wei

Chen

Yang

et al. 2021

Appl Biochem Biotechnol

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Aqueous two-phase systems (ATPS) have the advantages of environmentally friendly, high mass transfer efficiency, mild extraction conditions. However, it is difficult to recycle these components, which limits the large-scale application of ATPS in industrial production. In this study, a novel recyclable ATPS of PN/PADB4.78 was constructed with a thermo-responsive polymer PN and a pH-responsive polymer PADB4.78 for the partition study of tea saponin. The recovery of PN reached 98.71% by adjusting the temperature to above its lower critical solution temperature (LCST, 33.0 °C ) and the recovery of PADB4.78 was 97.32% by regulating the pH to its isoelectric point (pI, 4.78). Meanwhile, the phase formation mechanism of ATPS was studied by surface tension and low-field nuclear magnetic resonance (LF-NMR). The effects of polymer concentration, pH, temperature, types and concentrations of salt were investigated on tea saponin partition.In the 1.5% PN/3.5% PADB4.78 ATPS, the optimal partition coefficient (K) and extraction recovery (ERb) of crude tea saponin were 0.15 and 92.13% in the presence of 1.5 mM KCl at pH=7.6 and 25℃, respectively. The K and ERb of tea saponin from tea seeds were 0.12 and 94.50% with 7.5 mM LiBr at pH=8.0 and 25℃, respectively.

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“…When HCl or NaOH was added to the ATPS, the change of pH affected the hydrophilicity and hydrophobicity of the pH-responsive PADB4.78 [13]. The pH was too low to form ATPS.…”

Section: Effect Of Phmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Partition of Tea Saponin with a Novel Recyclable Thermo-pH Aqueous Two-Phase Systems

Wei

Chen

Yang

et al. 2021

Appl Biochem Biotechnol

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“…Stimuli-responsive polymers have gained great attention due to their promising applications in drug delivery, separations, filtration, smart surfaces, and regulating enzyme activity [ 1 , 2 , 3 , 4 , 5 ]. The stimuli can be classified as chemical stimuli, e.g., pH [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ] and chemical agents [ 15 , 16 , 17 ], and physical stimuli including temperature [ 8 , 10 , 12 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], electric or magnetic fields [ 26 , 27 , 28 ], and mechanical stress [ 29 , 30 , 31 ]. In all these stimuli, temperature is one of the most commonly used because of its easy control [ 19 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Polymers of Poly(2-(N-alkylacrylamide)ethyl acetate)s

et al. 2020

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Thermoresponsive poly(2-(N-alkylacrylamide) ethyl acetate)s with different N-alkyl groups, including poly(2-(N-methylacrylamide) ethyl acetate) (PNMAAEA), poly(2-(N-ethylacrylamide) ethyl acetate) (PNEAAEA), and poly(2-(N-propylacrylamide) ethyl acetate) (PNPAAEA), as well as poly(N-acetoxylethylacrylamide) (PNAEAA), were synthesized by solution RAFT polymerization. Unexpectedly, it was found that there are induction periods in the RAFT polymerization of these monomers, and the induction time correlates with the length of the N-alkyl groups in the monomers and follows the order of NAEAA < NMAAEA < NEAAEA < NPAAEA. The solubility of poly(2-(N-alkylacrylamide) ethyl acetate)s in water is also firmly dependent on the length of the N-alkyl groups. PNPAAEA including the largest N-propyl group is insoluble in water, whereas PNMAAEA and PNEAAEA are thermoresponsive in water and undergo the reversible soluble-to-insoluble transition at a critical solution temperature. The cloud point temperature (Tcp) of the thermoresponsive polymers is in the order of PNEAAEA < PNAEAA < PNMAAEA. The parameters affecting the Tcp of thermoresponsive polymers, e.g., degree of polymerization (DP), polymer concentration, salt, urea, and phenol, are investigated. Thermoresponsive PNMAAEA-b-PNEAAEA block copolymer and PNMAAEA-co-PNEAAEA random copolymers with different PNMAAEA and/or PNEAAEA fractions are synthesized, and their thermoresponse is checked.

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New methodologies and equipment used in new-generation separation and preconcentration methods

Azqhandi

Khezeli

Ghaedi

et al. 2020

New Generation Green Solvents for Separation and Preconcentration of Organic and Inorganic Species

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Synthesis of pH-responsive polymers forming recyclable aqueous two-phase systems and application to the extraction of demeclocycline

Cited by 17 publications

References 27 publications

Partition of Tea Saponin with a Novel Recyclable Thermo-pH Aqueous Two-Phase Systems

Partition of Tea Saponin with a Novel Recyclable Thermo-pH Aqueous Two-Phase Systems

Thermoresponsive Polymers of Poly(2-(N-alkylacrylamide)ethyl acetate)s

New methodologies and equipment used in new-generation separation and preconcentration methods

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