Synthesis of Phenyl-1,3,4-Thiadiazol-2-Amine Derivatives with in-Vitro Antioxidant Activity

Abstract

In this research, the synthesis of structurally important antioxidants 7-Hydroxy-4-Methyl Coumarin (C1) and 4-Hydroxy Coumarin derivatives was conducted. Coumarin was modified by various reaction steps for the production of target compounds. Different spectroscopic techniques characterized molecular structures FT-IR ,NMR. Antioxidant activity was carried out against 1,1diphenyl-2-picrylhydrazyl (DPPH) in vitro spectrophometric assays. Compared to ascorbic acid, all compounds exhibited high antioxidant efficiency. Among compounds, Compound 9 performance was considered to be the highest (92%), followed by compounds 8 and 10 (90%). Ascorbic acid has been used as a standard drug with inhibition of the percentage 90.5%.