Synthesis of PhTAD-substituted dihydropyrrole derivatives via stereospecific C–H amination

Gül, Melek; Elemes, Yiannis; Pelit, Emel; Dernektsi, Eleni; Georgiou, Dimitra K.; Oikonomou, Kosmas; Lis, Tadeusz; Szafert, Sławomir

doi:10.1007/s11164-016-2681-x

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Metal chelating (Fe +2 ions chelating) activity assay. The metal chelating activity of the compounds were made according to Decker and Welch, 1990 [13]. Compound activities were compared with standard antioxidant compounds EDTA, butylated hydroxytoluene (BHT) and Trolox (25-200 µg / mL).…”

Section: Synthesis Of Compound IImentioning

confidence: 99%

Investigation of antioxidant activity and effect on cell viability of pyrrolidine compounds in MCF-7 (breast cancer) and DLD-1 (colon cancer) cell lines

Mesci

Gül²,

Yıldırım³

2021

IJBCh

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In this study, it is aimed to investigate the effects of pyrrolidine compounds that are thought to be new drug candidates with effect on cell viability on cancer (MCF-7 and DLD-1) and normal (MCF-12A and CCD-18CO) cell lines. The effect on cell viability of the pyrrolidine compounds was determined for 24 hours at different concentrations (25-100 µM) on cancer (MCF-7 and DLD-1) and normal (MCF-12A and CCD-18CO) cell lines by comparing MTT and RTCA assays. The antioxidant activities of the pyrrolidine compounds were determined at different concentrations (25-200 mM) with DPPH, metal chelating and reducing methods. In addition, the calculation of the structural properties of the new pyrrolidine scaffolding with the DFT method was presented. It has been determined that pyrrolidine compounds reduce the number of MCF-7 cancer cells according to a negative control by half of and inhibit the DLD-1 cancer cells with the MTT method. IC 50 value for MCF-7 cell was determined as 100 µM. Metal chelation and DPPH activities have close results. The IC 50 value of DPPH activity of the compounds ranged from 108 to 142 µg/mL.

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Section: Synthesis Of Compound IImentioning

confidence: 99%

Investigation of antioxidant activity and effect on cell viability of pyrrolidine compounds in MCF-7 (breast cancer) and DLD-1 (colon cancer) cell lines

Mesci

Gül²,

Yıldırım³

2021

IJBCh

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“…PhTAD-substituted dihydropyrrole compounds (C) were synthesized according to our previous studies (Gul et al, 2017;Ayar et al, 2021). Thus, a 1 mmol concentration of dihydropyrrole solution in dichloromethane was added to the 1.1 mmol concentration of PhTAD at 25°C.…”

Section: Structure Of Compoundsmentioning

confidence: 99%

PhTAD-Substituted Dihydropyrrole Compounds Regulate Apoptotic Cell Death in MCF-7 Cells

Yazgan

Mesci

Akşahin

et al. 2021

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Breast cancer is the most common type of cancer amongst women. Apoptosis is known as a programmed cell death and this mechanism induces cancer cell death. Dihydropyrrole compounds contain a heterocyclic structure and these molecules have many biological effects including functioning as antioxidants and anticancer molecules. In this regard, the aim of this research was to investigate how PhTAD-substituted dihydropyrrole compounds affect the expression of apoptotic cell death proteins in the MCF-7 cells. The levels of Bax, Bcl-2, and cleaved caspase-3 proteins in the MCF-7 cells were measured using the ELISA method. The results revealed that CI, CII, CIII, CV, CVII, CVIII, CXI and CXII increased Bax, while CXIII and CXIV markedly decreased Bax. In addition, compounds CI, CII, CIII, CVII, CVIII, CXI and CXII upregulated Bcl2. Conversely, CIV, and CXIV downregulated Bcl2. Moreover, CIV and CXIV increased the Bax/Bcl2 ratio. However, CVIII and CXIII decreased Bax/Bcl2 ratio. In addition, CI, CIV, CIX and CXII treatment increased cleaved caspase-3 in MCF-7 cells compared to the negative control. These findings indicate that the PhTADsubstituted dihydropyrrole derivative molecules induced apoptotic proteins as a potential regulator of cancer cell death.

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ATP‐Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds

Yazgan¹,

Mesci²,

Akşahin³

et al. 2021

Ahi Evran Medical Journal

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Synthesis of PhTAD-substituted dihydropyrrole derivatives via stereospecific C–H amination

Cited by 3 publications

References 35 publications

Investigation of antioxidant activity and effect on cell viability of pyrrolidine compounds in MCF-7 (breast cancer) and DLD-1 (colon cancer) cell lines

Investigation of antioxidant activity and effect on cell viability of pyrrolidine compounds in MCF-7 (breast cancer) and DLD-1 (colon cancer) cell lines

PhTAD-Substituted Dihydropyrrole Compounds Regulate Apoptotic Cell Death in MCF-7 Cells

ATP‐Binding Cassette Transporters Mediated Chemoresistance in MCF-7 Cells: Modulation by PhTAD-Substituted Dihydropyrrole Compounds

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