Synthesis of physically crosslinked PVA/Chitosan loaded silver nanoparticles hydrogels with tunable mechanical properties and antibacterial effects

Kumar, Arun; Behl, Tapan; Chadha, Swati

doi:10.1016/j.ijbiomac.2020.02.048

Cited by 108 publications

(34 citation statements)

References 38 publications

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“…The tensile strength and tensile modulus indicate the toughness, and the elongation at break indicates the elasticity of the materials, suggesting their possible applications. The hydrogels of this study can be used for drug delivery applications such as antibiotic release because they have adequate (strong and flexible) mechanical properties [ 32 , 33 ]. Thus, several authors [ 34 , 35 ] reported the following values for the mechanical properties of wound dressing hydrogel films (TS = 18 MPa; E = 98; eB = 200%) and drug delivery films (TS = 13–35; eB = 44–112%), respectively.…”

Section: Resultsmentioning

confidence: 99%

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

et al. 2020

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A series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.

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Section: Resultsmentioning

confidence: 99%

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

et al. 2020

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“…Kumar et al also reported fabrication of polyvinyl alcohol- and CS-loaded AgNP hydrogels with good mechanical strength, antibacterial properties, and biocompatibility for wound dressings. 66 The material showed good inhibition toward S. aureus and E. coli . Li et al showed that silver NP-loaded collagen chitosan (CS) dressing (AgNP-CCD) can yield excellent antibacterial effects and play a good role in the healing of a second-degree burns.…”

Section: Metal Ion Releasementioning

confidence: 93%

Emerging Trends in Nanomaterials for Antibacterial Applications

Yougbaré¹,

Mutalik²,

Okoro³

et al. 2021

IJN

127

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Around the globe, surges of bacterial diseases are causing serious health threats and related concerns. Recently, the metal ion release and photodynamic and photothermal effects of nanomaterials were demonstrated to have substantial efficiency in eliminating resistance and surges of bacteria. Nanomaterials with characteristics such as surface plasmonic resonance, photocatalysis, structural complexities, and optical features have been utilized to control metal ion release, generate reactive oxygen species, and produce heat for antibacterial applications. The superior characteristics of nanomaterials present an opportunity to explore and enhance their antibacterial activities leading to clinical applications. In this review, we comprehensively list three different antibacterial mechanisms of metal ion release, photodynamic therapy, and photothermal therapy based on nanomaterials. These three different antibacterial mechanisms are divided into their respective subgroups in accordance with recent achievements, showcasing prospective challenges and opportunities in clinical, environmental, and related fields.

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“…Lately, synthetic polymers have been combined with natural polymers to enhance the biological and mechanical properties of hydrogels, such as chitosan/polyethylene glycol, 27,28 Ag/PAM, 29 polypyrrole/Ag hydrogel 30 and chitosan/PVA. [31][32][33] Designing economic hydrogels with desired properties is itself a big challenge in the scientific arena. In order to achieve the desired properties, it is also possible to combine different polymers, each of which contributes desired attributes.…”

Section: Introductionmentioning

confidence: 99%

Tough and flexible conductive triple network hydrogels based on agarose/polyacrylamide/polyvinyl alcohol and poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate

Azar

Dodda

Bělský

et al. 2021

Polymer International

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Herein, we demonstrate a simple and cost-effective way to fabricate conductive triple network hydrogels based on agarose (Ag), polyacrylamide (PAM) and poly(vinyl alcohol) (PVA) with a combination of physical-chemical crosslinked networks. The conductivity was generated by doping poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) into the triple network matrix of Ag-PAM-PVA. All hydrogels were homogeneous in the swollen state and incorporation of PEDOT:PSS did not influence the morphology significantly on a microscale, (light microscopy and cryogenic low-vacuum SEM). On the nanoscale, small-angle X-ray scattering showed some differences between hydrogels with/without PEDOT:PSS and also between double/triple networks. The tensile and compressive properties were enhanced at a lower concentration of PEDOT:PSS, with a maximum tensile strength of 0.47 MPa, at an elongation of 119%. Fortunately, all hydrogels have shown conductivity in the range of 0.3−1.5 mS cm −1 which is comparable with the conductivity of skin tissues and hence they can be conveniently optimized for use in biosensors or other devices related to skin/internal tissues.

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Synthesis of physically crosslinked PVA/Chitosan loaded silver nanoparticles hydrogels with tunable mechanical properties and antibacterial effects

Cited by 108 publications

References 38 publications

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

Sustained Release of Linezolid from Prepared Hydrogels with Polyvinyl Alcohol and Aliphatic Dicarboxylic Acids of Variable Chain Lengths

Emerging Trends in Nanomaterials for Antibacterial Applications

Tough and flexible conductive triple network hydrogels based on agarose/polyacrylamide/polyvinyl alcohol and poly(3,4‐ethylenedioxythiophene):polystyrene sulfonate

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