Synthesis of Plant Latex Based Hybrid Nanocarriers Using Surfactants for Curcumin Delivery

Samrot, Antony V.; Sahiti, K.; Bhavya, Karanam Sai; Suvedhaa, B.

doi:10.1007/s10876-018-1472-5

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…The absorbance maxima of aqueous extract was found at 270–280 nm and further no absorbance was recorded (Supplementary Fig. 2 ), which might be because of alkyl group present in latex 19 , 20 , where Samrot et al 21 reported Calotropis gigantea to show absorbance maxima at 228 nm. The crude latex showed peak near 3378 cm −1 and 3314 cm −1 indicated the -CH, -OH and -NH band stretching.…”

Section: Resultsmentioning

confidence: 94%

Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery

Samrot

Saigeetha

Mun

et al. 2021

Sci Rep

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Latex, a milky substance found in a variety of plants which is a natural source of biologically active compounds. In this study, Latex was collected from raw Carica papaya and was characterized using UV–Vis, FTIR and GC–MS analyses. Super Paramagnetic Iron Oxide Nanoparticles (SPIONs) were synthesized, coated with C. papaya latex (PL-Sp) and characterized using UV–Vis, FT-IR, SEM–EDX, XRD, VSM and Zeta potential analyses. SPIONs and latex coated SPIONs (PL-Sp) were used in batch adsorption study for effective removal of Methylene blue (MB) dye, where (PL-Sp) removed MB dye effectively. Further the PL-Sp was used to produce a nanoconjugate loaded with curcumin and it was characterized using UV–Vis spectrophotometer, FT-IR, SEM–EDX, XRD, VSM and Zeta potential. It showed a sustained drug release pattern and also found to have good antibacterial and anticancer activity.

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Section: Resultsmentioning

confidence: 94%

Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery

Samrot

Saigeetha

Mun

et al. 2021

Sci Rep

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“…Medicinal plants, including Calotropis gigantea , commonly called swallow wort or milkweed, and Euphorbia antiquorum , were used for the synthesis of nanocarriers for natural constituent (curcumin) delivery ( Samrot et al., 2019 ). Hence, the natural ingredients from plant latex can be encapsulated into nanosized biogenic structures.…”

Section: Latex-bearing Plants and Nanotechnologymentioning

confidence: 99%

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Mazur

Bałdysz²,

Warowicka³

et al. 2022

Front. Plant Sci.

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Latex-bearing plants have been in the research spotlight for the past couple of decades. Since ancient times their extracts have been used in folk medicine to treat various illnesses. Currently they serve as promising candidates for cancer treatment. Up to date there have been several in vitro and in vivo studies related to the topic of cytotoxicity and anticancer activity of extracts from latex-bearing plants towards various cell types. The number of clinical studies still remains scarce, however, over the years the number is systematically increasing. To the best of our knowledge, the scientific community is still lacking in a recent review summarizing the research on the topic of cytotoxicity and anticancer activity of latex-bearing plant extracts. Therefore, the aim of this paper is to review the current knowledge on in vitro and in vivo studies, which focus on the cytotoxicity and anticancer activities of latex-bearing plants. The vast majority of the studies are in vitro, however, the interest in this topic has resulted in the substantial growth of the number of in vivo studies, leading to a promising number of plant species whose latex can potentially be tested in clinical trials. The paper is divided into sections, each of them focuses on specific latex-bearing plant family representatives and their potential anticancer activity, which in some instances is comparable to that induced by commonly used therapeutics currently available on the market. The cytotoxic effect of the plant’s crude latex, its fractions or isolated compounds, is analyzed, along with a study of cell apoptosis, chromatin condensation, DNA damage, changes in gene regulation and morphology changes, which can be observed in cell post plant extract addition. The in vivo studies go beyond the molecular level by showing significant reduction of the tumor growth and volume in animal models. Additionally, we present data regarding plant-mediated biosynthesis of nanoparticles, which is regarded as a new branch in plant latex research. It is solely based on the green-synthesis approach, which presents an interesting alternative to chemical-based nanoparticle synthesis. We have analyzed the cytotoxic effect of these particles on cells. Data regarding the cytotoxicity of such particles raises their potential to be involved in the design of novel cancer therapies, which further underlines the significance of latex-bearing plants in biotechnology. Throughout the course of this review, we concluded that plant latex is a rich source of many compounds, which can be further investigated and applied in the design of anticancer pharmaceuticals. The molecules, to which this cytotoxic effect can be attributed, include alkaloids, flavonoids, tannins, terpenoids, proteases, nucleases and many novel compounds, which still remain to be characterized. They have been studied extensively in both in vitro and in vivo studies, which provide an excellent starting point for their rapid transfer to clinical studies in the near future. The comprehensive study of molecules from latex-bearing plants can result in finding a promising alternative to several pharmaceuticals on the market and help unravel the molecular mode of action of latex-based preparations.

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Physicochemical Characterization of Bioactive Compounds in Nanocarriers

Barros

Oliveira

Costa

et al. 2020

CPD

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: The encapsulation of bioactive compounds (BC) is an emerging technique for finding new medicines since it provides protection against degradation ambient factors before reaching the target site. Nanotechnology provides new methods for encapsulating BC and hence, for drug carrier development. Nanocarriers satisfactorily impact the absorption, distribution, metabolism and excretion rate when compared to conventional carriers. The nanocarrier material needs to be compatible and easily bind to the drug, and to be bio-resorbable. In this context, the physicochemical characterization of encapsulated BC is fundamental to guarantee quality, reproducibility and safety of the final pharmaceutical product. In this review, we present the physicochemical techniques mostly used today by researchers to characterize BC in nanocarriers, and the main information provided by each technique such as, morphology, size, crystallinity degree, long-term stability, efficacy of drug encapsulation, amount of BC released as a function of time and chemical bonds resulting from BC and nano-carrier interactions.

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Synthesis of Plant Latex Based Hybrid Nanocarriers Using Surfactants for Curcumin Delivery

Cited by 3 publications

References 24 publications

Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery

Utilization of Carica papaya latex on coating of SPIONs for dye removal and drug delivery

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Physicochemical Characterization of Bioactive Compounds in Nanocarriers

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