Synthesis of poly[2-(3-butenyl)-2-oxazoline] with abundant carboxylic acid functional groups as a fiber-based sol–gel reaction supporter for catalytic applications

Ying, Wu; Bae, Kihyeon; Ko, Na Yeong; Kim, Soo Hee; Ryu, Sam Gon; Zhu, Jin; Zhang, Ruoyu; Lee, Bumjae; Lee, Kyung Jin

doi:10.1016/j.jiec.2019.07.038

Cited by 4 publications

(4 citation statements)

References 59 publications

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“…46 PBuOxz n was modified by cysteamine hydrochloride and 3-mercaptopropionic acid to generate PBuOxz n -g-NH 2 and PBuOxz n -g-COOH, respectively. 63,64 The chemical structures and molecular characteristics were confirmed by FTIR, 1 H NMR, and 13 C NMR spectra and GPC (Figures S3b, S4d−e, S5d−e, and S6b).…”

Section: ■ Results and Discussionmentioning

confidence: 87%

“…Similarly, poly[2-(3-butenyl)-2-oxazoline] n (PBuOxz) n with various DPs ( n = 32, 41 and 80) and dispersity ( D̵ ) ≤ 1.30 were synthesized according to the reported procedure . PBuOxz n was modified by cysteamine hydrochloride and 3-mercaptopropionic acid to generate PBuOxz n - g -NH 2 and PBuOxz n - g -COOH, respectively. , The chemical structures and molecular characteristics were confirmed by FTIR, 1 H NMR, and 13 C NMR spectra and GPC (Figures S3b, S4d−e, S5d−e, and S6b).…”

Section: Resultsmentioning

confidence: 99%

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Nanoscale Polyelectrolyte Complex Vesicles from Bioinspired Peptidomimetic Homopolymers with Zwitterionic Property and Extreme Stability

et al. 2022

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The complexation of polyelectrolytes ranging from biomacromolecules to synthetic polymers offers a great opportunity to construct a new generation of hierarchical materials. Here, we report a new type of nanoscale peptidomimetic polyelectrolyte complex vesicles (PCVs), with excellent aqueous stability over time and a wide range of pH, assembled from a pair of oppositely charged bioinspired homopolypeptoids and homopoly(2oxazoline)s. This is distinct from the traditional homopolyelectrolytes that typically form microscale-sized liquid coacervates or solids. Through a systematic study, we demonstrated that the appropriate strength of hydrogen-bonding effects arising from the polar tertiary amide groups is significantly important for the formation of the vesicle. The prepared PCVs bearing water inner lumen are capable of encapsulating hydrophilic cargo molecules with good selectivity and tunable permeability, which can facilitate the diffusion of water-soluble therapeutic molecules, proteins, and enzymes. Due to the simultaneous surface display of positive and negative charges, the vesicles show excellent stability in physiological protein solutions and low toxicity, similar to known zwitterionic polymers. These superior properties combined with the facile preparation strategy suggest that the binary PCVs could be excellent drug delivery candidates for biomedical and engineering applications.

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Section: ■ Results and Discussionmentioning

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Nanoscale Polyelectrolyte Complex Vesicles from Bioinspired Peptidomimetic Homopolymers with Zwitterionic Property and Extreme Stability

et al. 2022

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“…27 The PBuOxz 80 precursor was subsequently quantitatively modified with cysteamine hydrochloride and 3-mercaptopropionic acid to obtain PBuOxz 80 -g-NH 2 and PBuOxz 80 -g-COOH, respectively. 34,35 The molecular structures and characteristics of these polymers were confirmed by 1 H NMR spectroscopy and GPC. The assemblies were prepared by mixing aqueous solutions of oppositely charged PBuOxz 80 -g-NH 2 and PBuOxz 80 -g-COOH at charge-matched stoichiometry and a total polymer concentration of 1 mg/mL at neutral pH in water.…”

Section: ■ Results and Discussionmentioning

confidence: 91%

“…Poly(2-oxazoline)s are peptidomimetic polymers that possess similar chemical structure to polypeptides yet are devoid of hydrogen-bond donating sites and chirality. − This results in tunable molecular interactions, processability, and excellent water affinity, offering an excellent nanoreactor platform. ,, By employing ring-opening polymerization (ROP) of BuOxz, we synthesized oppositely charged PBuOxz 80 with a degree of polymerization (DP) of 80 and a dispersity ( D̵ ) of 1.31 according to the reported procedure (Figures S2–S4). The PBuOxz 80 precursor was subsequently quantitatively modified with cysteamine hydrochloride and 3-mercaptopropionic acid to obtain PBuOxz 80 - g -NH 2 and PBuOxz 80 - g -COOH, respectively. , The molecular structures and characteristics of these polymers were confirmed by 1 H NMR spectroscopy and GPC.…”

Section: Resultsmentioning

confidence: 99%

Zwitterionic Polyelectrolyte Complex Vesicles Assembled from Homopoly(2-Oxazoline)s as Enzyme Catalytic Nanoreactors for Potent Anti-Tumor Efficiency

Wang,

Zhang,

Lin

et al. 2024

Langmuir

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Enzymes are known for their remarkable catalytic efficiency across a wide range of applications. Here, we present a novel and convenient nanoreactor platform based on zwitterionic polyelectrolyte complex vesicles (PCVs), assembled from oppositely charged homopoly(2-oxazoline)s, facilitating enzyme immobilization. We show remarkable enhancements in catalytic activity and stability by encapsulation of lipase as a model enzyme. Even as the temperature rises, the performance of the lipase remains robust. Further, the structural characteristics of PCVs, including hollow architecture and semipermeable membranes, endow them with unique advantages for enzyme cascade reactions involving glucose oxidase (GOx) and horseradish peroxidase (HRP). A decline in catalytic efficiency is shown when the enzymes are individually loaded and subsequently mixed, in contrast to the coloaded GOx−HRP−PCV group. We demonstrate that the vesicle structures establish confined environments where precise enzyme− substrate interactions facilitate enhanced catalytic efficiency. In addition, the nanoreactors exhibit excellent biocompatibility and efficient anti-tumor activity, which hold significant promise for biomedical applications within enzyme-based technologies.

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Optimizing chemical and mechanical stability of catalytic nanofiber web for development of efficient detoxification cloths against CWAs

Seo

Kim

Bae

et al. 2021

Polymer

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Synthesis of poly[2-(3-butenyl)-2-oxazoline] with abundant carboxylic acid functional groups as a fiber-based sol–gel reaction supporter for catalytic applications

Cited by 4 publications

References 59 publications

Nanoscale Polyelectrolyte Complex Vesicles from Bioinspired Peptidomimetic Homopolymers with Zwitterionic Property and Extreme Stability

Nanoscale Polyelectrolyte Complex Vesicles from Bioinspired Peptidomimetic Homopolymers with Zwitterionic Property and Extreme Stability

Zwitterionic Polyelectrolyte Complex Vesicles Assembled from Homopoly(2-Oxazoline)s as Enzyme Catalytic Nanoreactors for Potent Anti-Tumor Efficiency

Optimizing chemical and mechanical stability of catalytic nanofiber web for development of efficient detoxification cloths against CWAs

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