Synthesis of poly(acrylic acid) (PAA) modified Pluronic P123 copolymers for pH-stimulated release of Doxorubicin

Choo, Eugene Shi Guang; Yu, Bin; Xue, Junmin

doi:10.1016/j.jcis.2011.03.047

Cited by 36 publications

(25 citation statements)

References 31 publications

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“…A possible reason is that excess PDMAEMA chains extending from the micelles and the positive charges around the surface of the micelles create an effective shield against aggregation between micelles. For the low PDMAEMA‐to‐PBS ratios, the shorter PDMAEMA chains would suggest a lower surface charge due to the decreased PDMAEMA block content, reducing the shielding effect due to electrostatic repulsion, which resulted in aggregation of multiple micelles to form larger aggregates …”

Section: Resultsmentioning

confidence: 99%

Preparation of poly(butylene succinate)‐poly[2‐(dimethylamino)ethyl methacrylate] copolymers and their applications as carriers for drug delivery

Zhao

Guo

et al. 2018

Polymer International

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Copolymers of poly[2‐(dimethylamino)ethyl methacrylate]–poly(butylene succinate)–poly[2‐(dimethylamino)ethyl methacrylate] (PDMAEMA–PBS–PDMAEMA, PDBD) were synthesized through a chain‐extension reaction. The thermal properties characterized using differential scanning calorimetry showed that the introduction of PDMAEMA chains slightly decreased the melting temperature of PBS. The water contact angle of PDBD copolymer films with media of various pH decreased with a decrease of pH. This should be ascribed to the conformational transition of PDMAEMA blocks from a compact coil to an expanding shape in accordance with the variation of the pH of the surroundings. The results of dynamic light scattering and scanning electron microscopy revealed that PDBD copolymers could form spherical micelles with small particle size and narrow particle size distribution. Furthermore, drug loading (loading content, ca 10%; encapsulation efficiency, ca 60%) and release experiments were conducted using doxorubicin as a hydrophobic model drug. The results of release experiments of copolymer nanomicelles showed that these micelles had pH‐responsive properties. © 2018 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Preparation of poly(butylene succinate)‐poly[2‐(dimethylamino)ethyl methacrylate] copolymers and their applications as carriers for drug delivery

Zhao

Guo

et al. 2018

Polymer International

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“…The use of tert ‐butyl acrylate ( t BA) as monomer allows conducting the polymerization in an organic media compatible with the hydrophobic macroinitiator affinity at the required polymerization temperature (60 °C). Moreover, poly( tert ‐butyl acrylate) can be later easily hydrolysed in hydrophilic poly(acrylic acid) (PAA) . The difunctional amide based macroinitiator was then engaged in copper mediated ATRP of t BA with a Cu(I)Br/Cu(II)Br 2 /PMDETA catalytic system at 60 °C in toluene [Scheme (b)].…”

Section: Resultsmentioning

confidence: 99%

“…Poly(acrylic acid) (PAA), containing ionizable functions, is of considerable interest in drug delivery applications especially for its pH sensitivity . Furthermore, an improvement of the drug loading efficiency of a thermosensitive Pluronic® through the addition of PAA blocks at both ends was reported …”

Section: Introductionmentioning

confidence: 99%

Thermo‐ and pH‐sensitive triblock copolymers with tunable hydrophilic/hydrophobic properties

Pottier

Morandi

Dulong

et al. 2015

J. Polym. Sci., Part A: Polym. Chem.

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Polymers consisting of poly(acrylic acid) (PAA) and statistical poly[(acrylic acid)‐co‐(tert‐butylacrylate)] (P(AA‐co‐tBA)), attached to both extremities of Jeffamine® (D series based on a poly(propylene oxide) (PPO) with one amine function at each end) using atom transfer radical polymerization (ATRP) are presented in this article. An original bifunctional amide‐based macroinitiator was first elaborated from Jeffamine®. tBA polymerization was subsequently initiated from this macroinitiator. This polymerization occurs in a well‐controlled manner leading to narrow molecular weights distribution. Amphiphilic copolymers were finally obtained after complete or partial hydrolysis of the PtBA blocks into PAA. The control of the partial hydrolysis of tBA units, conducted in a concentrated HCl/tetrahydrofuran mixture, is demonstrated. The properties of the triblock copolymers were preliminary investigated in aqueous solution by absorbance, DLS measurements and SEC/MALS/DV/DRI analysis as a function of temperature and pH modifications, providing evidences of thermo‐ and pH‐sensitive self‐assembly of the copolymers. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 2606–2616

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“…This polymer is biodegradable by GI enzymes [14]. It is a mucoadhesive polyelectrolyte with COOH on its side chain [15] and deprotonated into carboxylate ions when the pH is greater than its pKa (4.75) [16]. Here, we used PAA to strengthen the drawbacks of Pluronic, such as weak gel strength, rapid erosion, and non-biodegradability [17].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Epirubicin in Thermogelling and Bioadhesive Liquid and Solid Suppository Formulations for Rectal Administration

Yi-Jun

Lin

2013

IJMS

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Temperature sensitive Pluronic (Plu) and pH-sensitive polyacrylic acid (PAA) were successfully mixed in different ratios to form in situ gelling formulations for colon cancer therapy. The major formulations were prepared as the liquid and solid suppository dosage forms. Epirubicin (Epi) was chosen as a model anticancer drug. In vitro characterization and in vivo pharmacokinetics and therapeutic efficacy of Epi in six Plu/PAA formulations were evaluated. Our in vitro data indicate that Epi in Plu 14%/PAA 0.75% of both solid and liquid suppositories possess significant cytotoxicity, strong bioadhesive force, long-term appropriate suppository base, sustained release, and high accumulation of Epi in rat rectums. These solid and liquid suppositories were retained in the upper rectum of Sprague-Dawley (SD) rats for at least 12 h. An in vivo pharmacokinetic study using SD rats showed that after rectal administration of solid and liquid suppositories, Epi had greater area under the curve and higher relative bioavailability than in a rectal solution. These solid and liquid suppositories exhibited remarkable inhibition on the tumor growth of CT26 bearing Balb/c mice in vivo. Our findings suggest that in situ thermogelling and mucoadhesive suppositories demonstrate a great potential as colon anticancer delivery systems for protracted release of chemotherapeutic agents.

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Synthesis of poly(acrylic acid) (PAA) modified Pluronic P123 copolymers for pH-stimulated release of Doxorubicin

Cited by 36 publications

References 31 publications

Preparation of poly(butylene succinate)‐poly[2‐(dimethylamino)ethyl methacrylate] copolymers and their applications as carriers for drug delivery

Preparation of poly(butylene succinate)‐poly[2‐(dimethylamino)ethyl methacrylate] copolymers and their applications as carriers for drug delivery

Thermo‐ and pH‐sensitive triblock copolymers with tunable hydrophilic/hydrophobic properties

Evaluation of Epirubicin in Thermogelling and Bioadhesive Liquid and Solid Suppository Formulations for Rectal Administration

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