Synthesis of poly hydroxypropyl methacrylate cryogel incorporated with Zn/Ce substituted hydroxyapatite nanoparticles for rejuvenation of femoral fracture treatment in a rat model

Zhou, Hongjie; Jiao, Huiping; Jing-wei, XU; Liu, Yulong; Wei, Shu‐Jun

doi:10.1016/j.jphotobiol.2019.111651

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…p-HEMA and p-HPMA are two other synthetic polymers which are largely used for medical devices application [110,111] and are also proposed for cartilage tissue repairing [57,112]. They are synthesized by polymerization of the monomers HEMA and HPMA.…”

Section: Other Natural Polymersmentioning

confidence: 99%

Cryogel Scaffolds for Tissue-Engineering: Advances and Challenges for Effective Bone and Cartilage Regeneration

Carriero,

Di Muzio,

Petralito

et al. 2023

Gels

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Critical-sized bone defects and articular cartilage injuries resulting from trauma, osteonecrosis, or age-related degeneration can be often non-healed by physiological repairing mechanisms, thus representing a relevant clinical issue due to a high epidemiological incidence rate. Novel tissue-engineering approaches have been proposed as an alternative to common clinical practices. This cutting-edge technology is based on the combination of three fundamental components, generally referred to as the tissue-engineering triad: autologous or allogenic cells, growth-stimulating factors, and a scaffold. Three-dimensional polymer networks are frequently used as scaffolds to allow cell proliferation and tissue regeneration. In particular, cryogels give promising results for this purpose, thanks to their peculiar properties. Cryogels are indeed characterized by an interconnected porous structure and a typical sponge-like behavior, which facilitate cellular infiltration and ingrowth. Their composition and the fabrication procedure can be appropriately tuned to obtain scaffolds that match the requirements of a specific tissue or organ to be regenerated. These features make cryogels interesting and promising scaffolds for the regeneration of different tissues, including those characterized by very complex mechanical and physical properties, such as bones and joints. In this review, state-of-the-art fabrication and employment of cryogels for supporting effective osteogenic or chondrogenic differentiation to allow for the regeneration of functional tissues is reported. Current progress and challenges for the implementation of this technology in clinical practice are also highlighted.

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Section: Other Natural Polymersmentioning

confidence: 99%

Cryogel Scaffolds for Tissue-Engineering: Advances and Challenges for Effective Bone and Cartilage Regeneration

Carriero,

Di Muzio,

Petralito

et al. 2023

Gels

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show abstract

“…In vitro tests confirmed that osteoblast cells (MG-63) show strong adhesion and growth in an attempt to create a ceaseless cell layer in the nano-composite cryogels while the measures of live microbes were clearly lower. Evidently, endochondral ossification detected In Vivo makes this material promising for clinical use in bone tissue engineering [ 166 ]. As another application, hydroxyapatite nanoparticles added to cryogel scaffold produced from silk-fibroin, chitosan, and agarose have been used for the controlled release of growth factors [ 110 ].…”

Section: Biodegradable Cryogelsmentioning

confidence: 99%

Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials

Zoughaib

Yergeshov

2021

Gels

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Cryogels obtained by the cryotropic gelation process are macroporous hydrogels with a well-developed system of interconnected pores and shape memory. There have been significant recent advancements in our understanding of the cryotropic gelation process, and in the relationship between components, their structure and the application of the cryogels obtained. As cryogels are one of the most promising hydrogel-based biomaterials, and this field has been advancing rapidly, this review focuses on the design of biodegradable cryogels as advanced biomaterials for drug delivery and tissue engineering. The selection of a biodegradable polymer is key to the development of modern biomaterials that mimic the biological environment and the properties of artificial tissue, and are at the same time capable of being safely degraded/metabolized without any side effects. The range of biodegradable polymers utilized for cryogel formation is overviewed, including biopolymers, synthetic polymers, polymer blends, and composites. The paper discusses a cryotropic gelation method as a tool for synthesis of hydrogel materials with large, interconnected pores and mechanical, physical, chemical and biological properties, adapted for targeted biomedical applications. The effect of the composition, cross-linker, freezing conditions, and the nature of the polymer on the morphology, mechanical properties and biodegradation of cryogels is discussed. The biodegradation of cryogels and its dependence on their production and composition is overviewed. Selected representative biomedical applications demonstrate how cryogel-based materials have been used in drug delivery, tissue engineering, regenerative medicine, cancer research, and sensing.

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“…Synthetic bone substitutes that have already been investigated involve metals, polymers, bioactive ceramics, etc. [6][7][8][9] Ideal synthetic bone substitutes should have the following properties: biocompatibility, osteogenic properties, antibacterial activity, biodegradability, and mechanical strength. 10 Although no single material can meet the above criteria simultaneously, various modification methods have been applied to optimize synthetic materials in bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

Wen,

Wang,

Pei

et al. 2023

J. Mater. Chem. B

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Synthesis of poly hydroxypropyl methacrylate cryogel incorporated with Zn/Ce substituted hydroxyapatite nanoparticles for rejuvenation of femoral fracture treatment in a rat model

Cited by 5 publications

References 34 publications

Cryogel Scaffolds for Tissue-Engineering: Advances and Challenges for Effective Bone and Cartilage Regeneration

Cryogel Scaffolds for Tissue-Engineering: Advances and Challenges for Effective Bone and Cartilage Regeneration

Design and Assessment of Biodegradable Macroporous Cryogels as Advanced Tissue Engineering and Drug Carrying Materials

Zinc-based biomaterials for bone repair and regeneration: mechanism and applications

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