Synthesis of poly(N-isopropylacrylamide)/poly(ethyl-2-cyanoacrylate) composite hollow particles

Lee, Yun Jig; Cheong, In Woo; Yeum, Jeong Hyun; Jeong, Yeon Uk

doi:10.1007/s13233-009-0171-3

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Nanogels synthesized using N-isopropyl acrylamide (NIPA) are enjoying a growing interest among specialists in drug formation technology, bioengineering and biocompatible polymers [4][5][6]. The wide interest in the polymers occurred because of their ability to secrete large amounts of water at a temperature referred to as the volume phase transition temperature (VPTT).…”

Section: Original Papersmentioning

confidence: 99%

The Conductivity and pH Values of Dispersions of Nanospheres for Targeted Drug Delivery in the Course of Forced Equilibrium Dialysis

Musiał¹,

Pluta²,

Byrski³

et al. 2015

Adv Clin Exp Med

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Background. In the available literature, the problem of pH and conductivity in FED is evaluated separately, and limited mainly to the final purity of the synthesized polymer. In this study data from conductivity and pH measurements were evaluated in the context of the structure of the macromolecule. Objectives. The aim of the study was to evaluate the conductivity and pH of dispersions of nanospheres synthesized with the use of N-isopropyl acrylamide (NIPA) as the main monomer, N,N'-methylenebisacrylamide (MBA) as the cross-linker and acrylic acid (AcA) as the anionic comonomer during the purification of dispersions via forced equilibrium dialysis (FED). Material and Methods. Six batches of nanospheres were obtained in the process of surfactant free precipitation polymerization (SFPP) under inert nitrogen. The conductivity and pH of the dispersions of nanospheres were measured at the beginning of FED and after finishing that process. The conductivity in the systems being studied decreased significantly in the process of FED. The initial values of conductivity ranged from 736.85 ± 8.13 μS × cm -1 to 1048.90 ± 67.53 μS × cm -1 After 10 days, when the systems being assessed gained stability in terms of conductivity level, the values of conductivity were between 4.29 ± 0.01 μS × cm -1 and 33.56 ± 0.04 μS × cm -1 . The pH values inreased significantly after FED. The resulting pH was between 6.92 ± 0.07 and 8.21 ± 0.07, while the initial values were between 3.42 ± 0.23 μS × cm -1 and 4.30 ± 0.22 μS × cm -1 . Conclusions. Conductivity and pH measurements performed during purification via FED provide important information on the composition of the resulting nanospheres, including the functional groups embedded in the structure of the polymer in the course of the synthesis, as well as the purity of the structures. The presence of a cross-linker and acidic comonomer in the poly-N-isopropyl acrylamide (polyNIPA) macromolecule may be confirmed by both the pH and the conductivity measurements (Adv Clin Exp Med 2015, 24, 2, 219-226).

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Section: Original Papersmentioning

confidence: 99%

The Conductivity and pH Values of Dispersions of Nanospheres for Targeted Drug Delivery in the Course of Forced Equilibrium Dialysis

Musiał¹,

Pluta²,

Byrski³

et al. 2015

Adv Clin Exp Med

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Development of degradable polymer composites from starch and poly(ethyl cyanoacrylate)

Kim

Peterson

2012

Polymer Composites

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This report describes the development of degradable polymer composites, which can be made at room temperature without special equipment. The developed composites are made from poly(ethyl cyanoacrylate) and starch. Ethyl cyanoacrylate monomers are mixed with starch and the polymerization reaction of these monomers was initiated by dissociated OH‐ ions from moisture on the surface of the starch. After the polymerization, the body of starch granules acts as filler and the micrometer‐scale gaps formed by starch granules are filled with the poly(ethyl cyanoacrylate). The glass transition temperature of the composite matrix ranges from 106°C to 113°C and thermal degradation begins around 160°C. The polymer composites produced by this procedure contain 50–64 wt% of starch and have compressive strengths of 80 (±10) MPa. Optimum starch composition for these composites is ∼60 wt%. POLYM. COMPOS., 2012. © 2012 Society of Plastics Engineers

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Poly(Alkyl Cyanoacrylate) Nanosystems

Nicolas

Vauthier

2011

Intracellular Delivery

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Synthesis of poly(N-isopropylacrylamide)/poly(ethyl-2-cyanoacrylate) composite hollow particles

Cited by 4 publications

References 29 publications

The Conductivity and pH Values of Dispersions of Nanospheres for Targeted Drug Delivery in the Course of Forced Equilibrium Dialysis

The Conductivity and pH Values of Dispersions of Nanospheres for Targeted Drug Delivery in the Course of Forced Equilibrium Dialysis

Development of degradable polymer composites from starch and poly(ethyl cyanoacrylate)

Poly(Alkyl Cyanoacrylate) Nanosystems

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