Synthesis of poly(orgnaophosphazenes) with glycolic acid ester and lactic acid ester side groups: prototypes for new bioerodible polymers

Allcock, Harry R.; Pucher, Shawn R.; Scopelianos, Angelo G.

doi:10.1021/ma00079a001

Cited by 71 publications

(33 citation statements)

References 8 publications

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“…4). Functionalization with amino acids makes the polymer hydrolytically degradable [193]. Sohn and colleagues have studied a variety of aspartic and glutamic acid derivatized polyphosphazenes conjugates of platinum drugs.…”

Section: Platinum Drug Delivery Using Nanocarriersmentioning

confidence: 99%

Nanocarriers for delivery of platinum anticancer drugs

Oberoi¹,

Nukolova²,

Kabanov³

et al. 2013

Advanced Drug Delivery Reviews

361

309

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Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patients, development of drug resistance, tumor relapse, and many other challenges have severely limited the patient quality of life. These limitations have motivated an extensive research effort towards development of new strategies for improving platinum therapy. Nanocarrier-based delivery of platinum compounds is one such area of intense research effort beginning to provide encouraging preclinical and clinical results and may allow the development of the next generation of platinum chemotherapy. This review highlights current understanding on the pharmacology and limitations of platinum compounds in clinical use, and provides a comprehensive analysis of various platinum–polymer complexes, micelles, dendrimers, liposomes and other nanoparticles currently under investigation for delivery of platinum drugs.

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Section: Platinum Drug Delivery Using Nanocarriersmentioning

confidence: 99%

Nanocarriers for delivery of platinum anticancer drugs

Oberoi¹,

Nukolova²,

Kabanov³

et al. 2013

Advanced Drug Delivery Reviews

361

309

View full text Add to dashboard Cite

show abstract

“…These include ethyl glycolate (15) [62] ethyl lactate (16) [62], glyceryl (17) [64], glucosyl (18) [41], and imidazolyl (19) groups [63]. Imidazolyl side groups have been utilized for controlled drug delivery experiments [64], but the others are also feasible candidates for future work in both tissue engineering and drug delivery.…”

Section: Other Bioerodible Polyphosphazenesmentioning

confidence: 99%

Expanding Options in Polyphosphazene Biomedical Research

Allcock

2008

Polyphosphazenes for Biomedical Applications

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“…Pphos was fabricated using a two-step preparative protocol in which an intermediate poly(dichloro phosphazene) was first produced by the thermal ring opening cationic polymerization of the cyclic trimer at 250°C. The reactive chlorine atoms of the intermediate were then replaced, in the presence of triethylamine, by the amino acid ester groups, ethyl phenylalanine and ethyl glycine [20-24]. …”

Section: Methodsmentioning

confidence: 99%

Novel factor-loaded polyphosphazene matrices: Potential for driving angiogenesis

Oredein-McCoy

Krogman

Weikel

et al. 2009

Journal of Microencapsulation

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Currently employed bone tissue engineered scaffolds often lack the potential for vascularization, which may be enhanced through the incorporation of and regulated release of angiogenic factors. For this reason, our objective was to fabricate and characterize protein-loaded amino acid ester polyphosphazene (Pphos)-based scaffolds and evaluate the novel sintering method used for protein incorporation, a method which will ultimately allow for the incorporation of proangiogenic agents. To test the hypothesis, Pphos and their composite microspheres with nanocrystalline hydroxyapatite (Pphos-HAp) were fabricated via the emulsion solvent evaporation method. Next, bovine serum albumin (BSA)-containing microsphere matrices were created using a novel solvent-non solvent approach for protein loading. The resulting protein (BSA) loaded-circular porous microsphere based scaffolds were characterized for morphology, porosity, protein structure, protein distribution, and subsequent protein release pattern. Scanning electron microscopy revealed porous microsphere scaffolds with a smooth surface and sufficient level of sintering, illustrated by fusion of adjacent microspheres. The porosity measured for the PNPhGly and PNPhGly-HAp scaffolds were 23 +/-0.11% and 18+/-4.02%, respectively, and within the range of trabecular bone. Circular dichroism confirmed an intact secondary protein structure for BSA following the solvent sintering method used for loading, and confocal microscopy verified that FITC-BSA was successfully entrapped both between adjacent microspheres and within the surface of the microspheres while sintering. For both Pphos and their composite microsphere scaffolds, BSA was released at a steady rate over a 21day time period, following a zero order release profile. HAp particles in the composite scaffolds served to improve the release profile pattern, underscoring the potential of HAp for growth factor delivery. Moreover, the results of this work suggests that the solvent nonsolvent technique for protein loading is an optimal one that will allow for future development of angiogenic factor loaded Pphos matrices with the capacity to invoke neovascularization.

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Synthesis of poly(orgnaophosphazenes) with glycolic acid ester and lactic acid ester side groups: prototypes for new bioerodible polymers

Cited by 71 publications

References 8 publications

Nanocarriers for delivery of platinum anticancer drugs

Nanocarriers for delivery of platinum anticancer drugs

Expanding Options in Polyphosphazene Biomedical Research

Novel factor-loaded polyphosphazene matrices: Potential for driving angiogenesis

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