Synthesis of poly(sebacic anhydride): effect of various catalysts on structure and thermal properties

Pavelková, Alena; Kucharczyk, Pavel; Zednı́k, Jiřı́; Sedlařík, Vladimír

doi:10.1007/s10965-014-0426-3

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…Furthermore, PSBA biodegradation is faster than the biodegradation of other polymers that are used as a matrix in IDDS (Po‐Lia et al, ). The fast biodegradation is a particularly significant property of PSBA, because during the implantation process, it is important to deliver the antibiotic dose immediately to the infected place or to the place threatened by infection (Brenza et al, ; Pavelkova, Kucharczyk, Zednik, & Sedlarik, ). Bone infection is a very dangerous illness because it is able to make the integration of bone tissue with implants difficult or even impossible.…”

Section: Introductionmentioning

confidence: 99%

Functionalization of PEO layer formed on Ti‐15Mo for biomedical application

et al. 2019

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In the present work, deposition of poly(sebacic anhydride) PSBA loaded by amoxicillin, cefazolin, or vancomycin on a previously anodized Ti‐15Mo surface is presented. PSBA loaded by the drug was deposited so as not to lose the functionality of the porous oxide layer microstructure. The morphology was evaluated using scanning electron microscopy, surface roughness, and wettability. The drug concentration was evaluated using high‐performance liquid chromatography. It was determined that the drugs were loaded into coatings in the range of 35.2–122.87 μg/cm2 of Ti sample. The drugs released more than 16% after 0.5 hr of the hybrid coating immersion in artificial saliva. After 3 days, the PSBA coatings were degraded by 51.3 mol %, and after 7 days by 77.8 mol %, which makes it possible to load the material by different, biologically active substances. An antimicrobial investigation of Staphylococcus aureus (DSM 24167) and Staphylococcus epidermidis (ATCC 700296) confirmed the activity of the hybrid layers against the pathogens. Hybrid layer with vancomycin best inhibits the adhesion of the bacteria, whereas coatings with amoxicillin and cefazolin showed a much better bactericidal activity. In this article, the difference in the obtained results is discussed, as well as the possibility of the application of this functional material in biomedicine.

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Section: Introductionmentioning

confidence: 99%