Synthesis of polyfluoroalkylated α-Aminophosphonic/thiophosphonic acids derivatives

An attempt to prepare sulfonyl analogues of fotemustine: unexpected rearrangement to sulfamate during nitrosation step

“…The 2-chloroethylureidophosphonate (AE)-20 was achieved with a 70% yield via nucleophilic addition of diethylamino(phenyl)methylphosphonate hydrochloride (AE)-19 with 2-chloroethyl isocyanate in basic conditions at 0 °C. 21 It was then treated with sodium nitrite (3 equiv.) using formic acid at low 0 °C in DCM for 2 hours.…”

6. Synthesis of α-aminophosphonates by the Kabachnik–Fields reaction and by the Pudovik reaction

“…N-Sulfonyl and N-carboxylic imine derivatives were also applied as starting materials in the Pudovik reaction to prepare the corresponding α-aminophosphonates [134][135][136][137].…”

Synthesis and ecotoxicological impact of ferrocene-derived amino-phosphonates using a battery of bioassays

“…Besides the diverse biological activities like enzyme inhibitors, antibiotics, or anticancer agents, substituted a-aminophosphonate derivatives have stimulated great interest as antiviral and antifungal agents and they have been extensively used as insecticides and herbicides. [19][20][21][22][23] Therefore, considering the biological values and possibilities in the chemical modication of a-amino-phosphonates, the growing concern and the development of new organophosphorus compounds are still of great interest. [24][25][26][27][28][29][30] Plant growth testgermination, growth inhibition, dry and fresh matter…”