Synthesis of polyglobalide by enzymatic ring opening polymerization using pressurized fluids

Collagen-decorated electrospun scaffolds of unsaturated copolyesters for bone tissue regeneration

“…S3 (ESI†). The melting temperatures of the pristine homopolymers (before electrospinning), 44 °C for PGL and 96 °C, agree with those from the literature, 46 °C 15 and 97 °C, respectively. 14 The lower T m of PGl is due to unsaturation, which is responsible for a more irregular and less packed structure.…”

“…After reaching the reaction temperature of 65 1C, the reaction proceeded for 2 h under magnetic stirring. The reaction conditions were chosen based on previous studies, [13][14][15] where similar macrolactones were employed in the synthesis of copolyesters. Novozyme 435 and its amount were chosen based on the results of previous works 36 that elucidated the effect of enzyme amount and enzyme nature on the kinetics of e-ROP.…”

“…For biomedical applications, the use of enzymes is particularly important because it results in polymers without any remaining toxicity, avoiding several purification steps, which are required when chemical catalysts are applied. 12 Lipases are capable of acting as a catalyst for e-ROP of several lactones and macrolactones, such as e-caprolactone, 12,13 o-pentadecalactone, 14 and globalide, 15 resulting in faster reactions under lower temperatures. 11 However, applying homopolymers derived from lactones in biomedical devices still presents some drawbacks, which are mainly related to their high hydrophobicity, low hydrolysis rate, and poor resorbability.…”