Synthesis of Polyhydroxybutyrate Nanoparticles Using Surfactant (Span20) for Hydrophobic Drug Delivery

Senthilkumar, P.; Dawn, S.S.; C, SaiPriya; Samrot, Antony V.

doi:10.31788/rjc.2018.1144053

Cited by 13 publications

(17 citation statements)

References 2 publications

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“…The surfactant helps to create a stable shape with hollow cavities, where the encapsulation efficiency of the lipophilic drugs is increased [ 198 , 199 ]. Senthilkumar et al [ 200 ] prepared PHB-based nanoparticles using SPAN 20 as a surfactant which were then loaded with a hydrophobic curcumin drug. The nanoparticles were found to be below 300 nm in size and spherical in shape.…”

Section: Phas In Nanotechnologymentioning

confidence: 99%

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

et al. 2021

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Polyhydroxyalkanoates (PHAs) are storage granules found in bacteria that are essentially hydroxy fatty acid polyesters. PHA molecules appear in variety of structures, and amongst all types of PHAs, polyhydroxybutyrate (PHB) is used in versatile fields as it is a biodegradable, biocompatible, and ecologically safe thermoplastic. The unique physicochemical characteristics of these PHAs have made them applicable in nanotechnology, tissue engineering, and other biomedical applications. In this review, the optimization, extraction, and characterization of PHAs are described. Their production and application in nanotechnology are also portrayed in this review, and the precise and various production methods of PHA-based nanoparticles, such as emulsion solvent diffusion, nanoprecipitation, and dialysis are discussed. The characterization techniques such as UV-Vis, FTIR, SEM, Zeta Potential, and XRD are also elaborated.

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Section: Phas In Nanotechnologymentioning

confidence: 99%

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

et al. 2021

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“…[1][2][3] Nanoparticles may be synthesized using various cost-effective and eco-friendly methods such as sol-gel method, green synthesis and nanoprecipitation technique. [4][5][6][7] Surface functionalized magnetite nanoparticles have become more popular among researchers due to their vast applications. The surface functionalization of magnetite nanoparticles with protein enhances the capabilities of these nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Surface Functionalization of Magnetite Nanoparticles and Their Antibacterial Studies

Singh¹,

Jangra²,

Kumar³

et al. 2020

RJC

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In the present paper the synthesis of magnetite nanoparticles and their surface functionalization with protein has been described. Surface functionalization of these nanoparticles was confirmed using various techniques including Transmission Electron Microscopy, X-Ray Diffraction, Vibrating Scanning Magnetometry, Thermo-gravimetric studies and Fourier Transform Infrared Spectroscopy. Further, surface-functionalized magnetite nanoparticles were loaded with ciprofloxacin drug and then screened for their antibacterial activity against two gram-positive (Bacillus subtilis and Staphylococcus aureus) and two gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacterial strains.

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“…To suppress the competition of using crude oil as surfactant sources as well as to develop a biodegradable surfactant, some novel biosurfactants have been prepared and evaluated [6][7][8][11][12][13][14] . Some biosurfactants have been developed and reported 15,16 , however, the recent interest in the nonionic surfactants based on edible oil keeps growing on due to their high thermal stability, biodegradability and high chemical stability 14,[17][18] . The physicochemical properties of biosurfactants depend on the lengths of the alkyl chains as well as the presence of the substituents on the alkyl chains.…”

Section: Introductionmentioning

confidence: 99%

Diethanolamide Derivatives as a Potential Enhanced Oil Recovery Agent From Indonesian Castor Oil and Used Frying Oil: Isolation, Synthesis, and Evaluation as Nonionic Biosurfactants

Wahyuningsih¹,

Kurniawan²,

Amalia³

et al. 2019

RJC

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Mono-, di-and trihydroxy fatty acids were reacted in a free-solvent amidation reaction with diethanolamine to obtain the derivative of dialkanolamides.The ricinoleic acid and 9,10,12-trihydroxystearic acid were isolated and prepared from Indonesian castor oil, while 9,10-dihydroxystearic acid was synthesized from the used frying oil. Amidation reaction of methyl ricinoleate, 9,10-dihydroxystearic acid and 9,10,12-trihydroxystearic acid gave the dialkanolamide derivatives in 93.10, 49.66, and 38.78% yield, respectively. The chemical structure of the synthesized products was elucidated by FTIR and GC-MS through silylation method. The prepared compounds were evaluated for their physicochemical properties as nonionic biosurfactant such as Hydrophilic-Lyophilic Balance value, interfacial tension, critical micelle concentration, foam stability, emulsification index, and emulsion stability. It was found that more hydroxyl groups contribute to a higher Hydrophilic-Lyophilic Balance value, foam stability, emulsification index, and lower interfacial tension.

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Synthesis of Polyhydroxybutyrate Nanoparticles Using Surfactant (Span20) for Hydrophobic Drug Delivery

Cited by 13 publications

References 2 publications

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

The Synthesis, Characterization and Applications of Polyhydroxyalkanoates (PHAs) and PHA-Based Nanoparticles

Synthesis, Characterization, Surface Functionalization of Magnetite Nanoparticles and Their Antibacterial Studies

Diethanolamide Derivatives as a Potential Enhanced Oil Recovery Agent From Indonesian Castor Oil and Used Frying Oil: Isolation, Synthesis, and Evaluation as Nonionic Biosurfactants

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