“…After methanolysis, the desired product 6a was isolated in 62% yield together with 22% of the deiodinated product 3a, resulting from a competitive lithium/iodine exchange, as already reported in the literature. 55,56,82,83,87 Pleasingly, it was possible to perform the reaction on a 16 mmol scale with slightly better results (6a, 79% yield). Using Eschenmoser's salt to trap the lithiated intermediate afforded the 1,2,3,4-tetrasubstituted derivative 6b in 68% yield while the use of methyl chloroformate only afforded the ester 6c in a surprising low 2% yield.…”