Synthesis of Potent and Selective Inhibitors Against the Proliferation of Human Coronary Artery Smooth Muscle Cells.

Abstract

III) and (VI) are synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells. Derivative (VIb) is much superior to Tranilast, in terms of both the potency of its inhibitory activity toward the proliferation of (SMCs) and the cell selectivity. -(OGITA, H.; ISOBE, Y.; TAKAKU, H.; SEKINE, R.; GOTO, Y.; MISAWA, S.; HAYASHI*, H.; Chem. Pharm. Bull. 51 (2003) 2, 117-121; Pharm. Biotechnol. Lab., Japan Energy Corp., Toda, Saitama 335, Japan; Eng.) -M. Paetzel 30-118