Synthesis of Potential Antineoplastic Agents I

Roll, William D.

doi:10.1002/jps.2600530628

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Series Of Derivatives Of Aa-diphenyl-4-1

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1965

1995

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Cited by 3 publications

(1 citation statement)

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“…This report describes the synthesis of some Nhaloacyl analogs of this amine. Based on the report by Carbon and co-workers (I) that various bis-haloamides demonstrate antitumor activity, a group of diphenamide derivatives have been reported previously ( 2 ) . The compounds reported herein are halopropionyl and haloacetyl derivatives of a 4-aralkylpiperidine.…”

Section: Series Of Derivatives Of Aa-diphenyl-4-mentioning

confidence: 99%

Synthesis of Several N-Haloacyl Analogs of α,α-Diphenyl-4-piperidinemethanol as Potential Antineoplastic Agents

Roll

1965

Journal of Pharmaceutical Sciences

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Section: Series Of Derivatives Of Aa-diphenyl-4-mentioning

confidence: 99%

Synthesis of Several N-Haloacyl Analogs of α,α-Diphenyl-4-piperidinemethanol as Potential Antineoplastic Agents

Roll

1965

Journal of Pharmaceutical Sciences

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Synthesis of small‐medium ring thioanhydrides

Kates

Schauble

1995

Journal of Heterocyclic Chem

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Reaction of five‐membered ring anhydrides with sodium sulfide has previously been employed for synthesis of the corresponding thioanhydrides in low yields. Re‐examination of the stoichiometry reveals reaction of cyclic anhydride with sodium sulfide (2:1 respectively), affords the thioanhydride accompanied by the corresponding dicarboxylate in a 1:1 molar ratio. The mechanistic pathway for this reaction has also been elucidated. Optimization of reaction conditions has resulted in the synthesis of a variety of four to seven‐membered ring thioanhydrides in yields approaching theoretical.

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Synthesis of Potential Antineoplastic Agents I

Cited by 3 publications

References 6 publications

Synthesis of Several N-Haloacyl Analogs of α,α-Diphenyl-4-piperidinemethanol as Potential Antineoplastic Agents

Synthesis of Several N-Haloacyl Analogs of α,α-Diphenyl-4-piperidinemethanol as Potential Antineoplastic Agents

Synthesis of small‐medium ring thioanhydrides

Synthesis of Several N,N′-Haloacyl Analogs of N,N′-Diphenylethylenediamine as Potential Antineoplastic Agents

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