Synthesis of Prodelphinidin Trimer Isolated from Cistus Albidus and its Growth Inhibitory Activity Against Human Prostate Cancer Cell Lines

Cistus albidus L.—Review of a Traditional Mediterranean Medicinal Plant with Pharmacological Potential

“…In the field of cancer research, evidence suggests that 13-epi-manoyl oxide, a characteristic labdane-type diterpene of C. albidus, may play a pivotal role in antitumor activity, inducing apoptosis in leukemic cell lines through multiple pathways [ 170 , 312 , 313 , 314 ]. Flavanols such as prodelphinidins and epigallocatechin-gallocatechin-catechin oligomers were also shown to exert a significant growth-inhibitory activity against human prostate cell lines by blocking cell cycle partly at the G1/G0 phase and activating caspase-3, as was shown for prodelphinidins extracted from C. albidus [ 14 ], synthetic prodelphinidins [ 315 ], and oligomeric proanthocyanidins from Vigna angularis [ 316 ]. The cytotoxic effect was suggested to be related with the presence of the pyrogallol moiety [ 14 ].…”

“…Flavanols such as prodelphinidins and epigallocatechin-gallocatechin-catechin oligomers were also shown to exert a significant growth-inhibitory activity against human prostate cell lines by blocking cell cycle partly at the G1/G0 phase and activating caspase-3, as was shown for prodelphinidins extracted from C. albidus [ 14 ], synthetic prodelphinidins [ 315 ], and oligomeric proanthocyanidins from Vigna angularis [ 316 ]. The cytotoxic effect was suggested to be related with the presence of the pyrogallol moiety [ 14 ]. However, due to the composition of C. albidus , future applications could focus on the prevention of neurodegenerative diseases.…”

“…Currently, its use as a medicinal plant is vestigial; however, its phytochemical composition, especially the combination of some terpenoids and polyphenols, makes it a promising species with many pharmacological activities. Pharmacological studies on extracts of C. albidus have shown their antioxidant, antibacterial, antifungal [ 5 , 11 , 12 ], antinociceptive [ 13 ], and anticarcinogenic [ 5 , 14 ] activity, in addition to other potential activities discussed later in this review.…”