Synthesis of pyrano[3,2-c]quinolones and furo[3,2-c]quinolonesviaacid-catalyzed tandem reaction of 4-hydroxy-1-methylquinolin-2(1H)-one and propargylic alcohols

Abstract

Two acid-catalyzed tandem reactions between 4-hydroxy-1-methylquinolin-2(1H)-one and propargylic alcohols are described.

Synthesis of Cyclohepta[b]indoles and Furo[3,4-b]carbazoles from Indoles, Tertiary Propargylic Alcohols, and Activated Alkynes

“…As part of our continuing efforts on heterocycle formation using readily available starting materials (propargylic alcohols) under mild conditions, herein, we describe a general three-component approach to cyclohepta­[ b ]­indoles and furo­[3,4- b ]­carbazoles from indoles, tertiary propargylic alcohols, and activated alkynes under mild metal-free conditions without the use of any expensive reagents (Scheme b).…”