Synthesis of Pyrazolyl Methylene Bisindoles by using Recyclable Nano Copper Ferrite Catalyst and their Anti Bacterial Studies

Abstract

A novel and eco friendly procedure for the synthesis of novel 3, 3'-((1, 3-diphenyl-1H-pyrazol-4-yl) methylene) bis (1H-indole) derivatives has been developed through the reaction of 1,3-diphenyl-1H-pyrazole-4-carbaldehyde and1H-indole using low cost and recyclable Nano copper ferrite catalyst. This novel method offers several advantages, such as high yields, short reaction time, environmental friendly reaction media and recyclable catalyst. The synthesized compounds were confirmed by H 1 , C 13 NMR and Mass Spectral analysis. The drug likeness or drugability of all the synthesized compounds were tested through rule of five (RO5) parameters. All the compounds have shown one or more RO5 violations. The compounds were screened for their antibacterial activity against both gram positive and gram negative bacteria. Four of the synthesized compounds (3a, 3b, 3l and 3i) were found to possess significant antibacterial activity against human pathogenic bacteria. All the four compounds showed RO5 violations.