2023
DOI: 10.1002/adsc.202300908
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Synthesis of Pyrido‐[2,1‐a]isoquinoline Derivatives via Gold(I)‐Catalyzed Intramolecular Cascade Reaction of Enamides

Xin‐Ming Xu,
Sen Chen,
Wenzhong Li
et al.

Abstract: A gold(I)‐catalyzed intramolecular cascade reaction of tertiary enamides has been developed, which provides a method for the preparation of diverse pyrido[2,1‐a]isoquinoline derivatives with good function group tolerance. Preliminary investigation of the reaction mechanism indicate that this process comprises a nucleophilic addition of the enamide to an alkynyl group, followed by the capture of the acyliminium ion by an electron‐rich aromatic component. Additionally, scale‐up experiments and further transforma… Show more

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