Synthesis of Pyrimidin‐2‐ones and Imidazolin‐2‐ones.

Harode, Raju; Sharma, T. C.

doi:10.1002/chin.200310043

Cited by 2 publications

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“…The key compound 3‐methyl‐1‐thiocarbamoyl‐2‐pyrazolin‐5‐one ( 1 ) was prepared by the reaction of ethyl acetoacetate with thiosemicarbazide according to the previously reported methodology . The reactivity of methylene group in compound 1 was investigated toward the electrophilic diazocoupling reaction with the aromatic diazonium chloride of ethyl 4‐amino benzoate ( 2 ); the reaction proceeded in pyridine to afford the corresponding 4‐arylhydrazono‐1‐thiocarbamoyl‐2‐pyrazolin‐5‐one derivative 3 (Scheme ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antioxidant Activity of Some New Thiazolyl–Pyrazolone Derivatives

Gaffer

Abdel-Fattah

Etman

et al. 2016

Journal of Heterocyclic Chem

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3‐Methyl‐1‐thiocarbamoyl‐2‐pyrazolin‐5‐one has been utilized as a core for the synthesis of some 1‐(thiazol‐2‐yl)‐pyrazolin‐5‐one derivatives through diazo‐coupling reaction and/or Knoevenagel condensation followed by heterocyclization with some α‐halogenated reagents such as bromoacetone, phenacyl bromide, and ethyl bromoacetate. Base prompted addition of the core compound to an equimolar amount of phenyl isothiocyanate furnished 3‐methyl‐4‐phenylthiocarbamoyl‐1‐thiocarbamoyl‐2‐pyrazolin‐5‐one which undergoes heterocyclization with α‐halogenated reagents at the more reactive phenylthiocarbamoyl moiety to afford the corresponding 4‐(thiazol‐2‐yl)‐1‐thiocarbamoyl‐2‐pyrazolin‐5‐ones. The new synthesized thiazolyl–pyrazolone compounds were evaluated for their potential antioxidant activity by using (ABTS Radical Cation Decolorization Assay).

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Section: Resultsmentioning

confidence: 99%

Synthesis and Antioxidant Activity of Some New Thiazolyl–Pyrazolone Derivatives

Gaffer

Abdel-Fattah

Etman

et al. 2016

Journal of Heterocyclic Chem

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“…Steroidal dibromoketone 1 7 on treatment with thiourea [8][9][10][11][12] in ethyl alcohol afforded a solid compound which was analyzed for C 28 The same steroidal ketone 1 on similar treatment with urea 9-12 and guanidine hydrochloride [13][14][15] …”

Section: Resultsmentioning

confidence: 99%

Synthesis of Steroidal Diazolidinone, Diazolidinthione and Diazoles: Reaction of Steroidal Dibromoketones With Nucleophilic Nitrogen

Shamsuzzaman

Baqi

2014

J. Chil. Chem. Soc.

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Reaction of 5,6β-dibromo-5α-cholestan-3-one 1 with thiourea, urea and guanidine hydrochloride provided 3-hydroxycholest-3-eno [5α,6α-d] 1',3'-diazolidin-2'-thione 2, 3-hydroxycholest-3-eno [5α,6α-d] 1',3'-diazolidin-2'-one 3 and 3-hydroxycholest-3-eno [5α,6α-d] 2'-amino-1',3'-diazole 4 respectively. The structures of these products have been established on the basis of their elemental analysis and spectral data (IR, 1 H NMR and MASS).

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Synthesis of Pyrimidin‐2‐ones and Imidazolin‐2‐ones.

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 2 publications

References 1 publication

Synthesis and Antioxidant Activity of Some New Thiazolyl–Pyrazolone Derivatives

Synthesis and Antioxidant Activity of Some New Thiazolyl–Pyrazolone Derivatives

Synthesis of Steroidal Diazolidinone, Diazolidinthione and Diazoles: Reaction of Steroidal Dibromoketones With Nucleophilic Nitrogen

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