Synthesis of pyrimidine carboxamide derivatives catalyzed by uranyl nitrate hexa Hydrate with their antibacterial and antioxidant studies

Abstract

ABSTRACT. An efficient and simple method was developed for the synthesis pyrimidine-5-carboxamides using UO2(NO3)2.6H2O catalyst under conventional and microwave irradiation. The synthesis of dihydropyrimidine using uranyl nitrate had shown many advantages such as easy work up, shorter reaction times and higher yields using acetonitrile as a solvent. The structures of the synthesized compounds were confirmed by FT-IR, 1 H NMR, 13 C NMR and mass spectral data. All the synthesized compounds screened for in vitro antioxidant and antibacterial activity and the results are reported.

Synthesis, Physical Chemistry, Molecular Docking, Bioactivities and Antioxidant Activity of α–Amino Phosphonates Based on Phenothiazine Using PEG–400 as Green Catalyst

“…The starting materials were synthesized according to the literature procedure with slight modification explained in the experimental section and their spectroscopic data and melting points compared to those reported in the literature in order to correctly identify the starting materials for the next step of synthesis . The compounds ( 5a–j ) exhibited infrared absorption bands for N−H, P=O and P−C aliphatic bands in the regions 3264–3368, 1232–1238 and 747–758 cm −1 respectively.…”

Exceedingly facile one-pot protocols to the synthesis of pyrimido annulated analogues of carbazolo condensed azepinones and their evaluation for analgesic activity

“…Literature is replete with examples showing that heterocycles which incorporate carbazoles [1], azepinones [2] and pyrimidines [3] in their molecular framework display wide range of bioefficacies such as anti-cancer [4], anti-leukemic [5], antiproliferative [6], anti-microbial [7], anti-viral [8], anti-malarial [9], antioxidant [10], etc. Ever since, pyrimidine derivatives have been recognized to belong to the class of 'privileged medicinal scaffolds' [11] its potential have been widely exploited in the discovery of such pyrimidine based drugs as 'Etravirine' [12] which has emerged as a highly potent anti-HIV agent, to have found the FDA approval for the treatment of AIDS.…”

“…from easily accessible starting materials, we report herein in this communication, the preliminary results of our study on the synthesis of pyrimidine annulated analogues of carbazolo fused azepinones(8)(9)(10)(11)(12)(13)(14)(15) from 7-ethyl-3,4-dihydroazepino[3,2-b] carbazol-2,5(1H,7H)-dione (3) [18]. A perusal of literature on the preparation of oxoketenedithioacetals, 2-(dimethylaminomethylene) ketones, oxoenolethers and α,βunsaturated ketones (chalcones), demonstrated that these were readily available from the base catalyzed condensation of carbonyl species containing an active methylene group with (i) CS 2 + MeI (ii) DMF-DMA (iii) HCOOEt and (IV) C 6 H 5 CHO respectively.…”

“…Application of this strategy on 3 afforded the intermediates 4-7 in moderate to good yield. The versatility of these novel precursors in heteroannulations of 3 was examined by allowing 4-7 derivatives to react with urea, thiourea, acetamidine and guanidine, which resulted the desired pyrimidine annulated analogues(8)(9)(10)(11)(12)(13)(14)(15) in acceptable yields. Compound 3 was in turn realized from the commercial 3amino-9-ethyl carbazole (1) on its reaction with ethyl succinyl chloride under the conditions of Friedel-Crafts acylation, followed by cyclocondensation of the resulting intermediate with PPA.…”

Novel synthesis, ring transformation and anticancer activity of 1,3-thiazine, pyrimidine and triazolo[1,5-a]pyrimidine derivatives

“…1,3-Thiazine derivatives are class of compounds with potential biological activity, such as growth promoting activities [1], anti-fungal activity [2], antiproliferative [3], anti-tumor activity [4], anticancer [5], analgesic activity [6,7], calming activity [8], anticonvulsant activity [9], antibiotic alctivity [10,11], anti-inflammatory [11,12], antimicrobial [13], antimycobacterial [14], antibacterial [15] and antihypertesive [7,16]. On the other hand, pyrimidine derivatives are known to be biologically active compounds and have shown wide range of biological activities like antitubercular [17], antimicrobial, antioxidant and anti-inflammatory [18][19][20], anticancer [21], analgesic, anti-fungal activity, anti-leishmanial, antiviral activity [22,23]. Recently, our research field focused to design and synthesis of biologically active heterocyclic compounds from readily available reagents [24][25][26].…”