Synthesis of pyrrole-2-carboxylic acids and their N-vinyl derivatives

Собенина, Л. Н.; Sergeeva, M. P.; Михалева, А. И.; Sigalov, M. V.; Korostova, S. E.; Golovanova, N. I.; Salaurov, V.N.; Bakhareva, E. V.; Васильева, Н. Н.

doi:10.1007/bf00487424

Cited by 2 publications

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“…The method described here offers a significant advantage, in terms of overall synthetic steps and availability of starting materials, over existing methods for the preparation of 5-arylpyrrole-2-carboxylic acids. 15,[21][22][23] Compounds 3a-j were prepared in 1-10 gram scale from a single reaction run, and no chromatographic purification was necessary.…”

Section: Table 2 Arylation Of Pyrrole With Phenyl Bromide To Form 1imentioning

confidence: 99%

Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors

et al. 2017

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Section: Table 2 Arylation Of Pyrrole With Phenyl Bromide To Form 1imentioning

confidence: 99%

Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors

et al. 2017

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“…Pyrrolecarboxylic acid exhibit higher biological activity. Derivatives of 5-pyrrolecarboxylic acid possess an antiviral effect, in particular, they actively suppress classical fowl plague viruses [2] and the sodium salt of 2-aryl-5-pyrrolecarboxylic acid exhibit anticonvulsant activity [3]. The aim is the creation of physical-chemical model of synthesis of methyl 5-acetyl-2-pyrrolecarboxylic acid reacting 2-acetylpyrrolyl with carbon tetrachloride and methanol under the influence of iron catalysts and carrying out its formalization, t. E. Drawing up a mathematical model, which is a system of relations reflecting the basic conservation laws (mass, energy, momentum, etc.).…”

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confidence: 99%

Building a Mathematical Model Synthesis of Methyl Ether 5-Acetyl-2- Pyrrolecarboxylic Acid

2015

American Research Journal of Mathematics

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Currently, mathematical modeling has become a common method of scientific knowledge and the creation of objects in many fields of science and technology. For chemical engineering simulation is the theoretical basis and method of solving the problems associated with the definition of the optimal conditions of catalytic processes and the creation of complex automation systems. Mathematical modeling of catalytic processes allows, without resort to complicated and expensive natural experiments designed to explore the many features of the processes, use mathematical optimization techniques in order to find the optimum operating conditions. The general scheme of mathematical modeling was formulated by academician AA Samarskim [1]. Catalytic synthesis reaction of aromatic and heterocyclic compounds, such as synthesis of methyl ether 5-acetyl-2-pyrrolecarboxylic acid, possess a wide range of applications. Methyl ether 5-acetyl-2-pyrrolecarboxylic acid of great interest to obtain porphyrins and drugs. Pyrrolecarboxylic acid exhibit higher biological activity. Derivatives of 5-pyrrolecarboxylic acid possess an antiviral effect, in particular, they actively suppress classical fowl plague viruses [2] and the sodium salt of 2-aryl-5-pyrrolecarboxylic acid exhibit anticonvulsant activity [3]. The aim is the creation of physical-chemical model of synthesis of methyl 5-acetyl-2-pyrrolecarboxylic acid reacting 2-acetylpyrrolyl with carbon tetrachloride and methanol under the influence of iron catalysts and carrying out its formalization, t. E. Drawing up a mathematical model, which is a system of relations reflecting the basic conservation laws (mass, energy, momentum, etc.).

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Synthesis of pyrrole-2-carboxylic acids and their N-vinyl derivatives

Cited by 2 publications

References 3 publications

Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors

Synthesis of 5-Arylpyrrole-2-carboxylic Acids as Key Intermediates for NBD Series HIV-1 Entry Inhibitors

Building a Mathematical Model Synthesis of Methyl Ether 5-Acetyl-2- Pyrrolecarboxylic Acid

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