2024
DOI: 10.1002/adsc.202301458
|View full text |Cite
|
Sign up to set email alerts
|

Synthesis of Quinine‐Inspired Antimalarials by Ni‐Catalysed Cross Electrophile Coupling

Aggie Lawer,
Finlay P. Player,
Vicky M. Avery
et al.

Abstract: We describe the efficient synthesis of novel dehydroxyquinines by arylation of quincorine bromide using Ni‐catalysed cross electrophile coupling. The method demonstrates robust compatibility with (hetero)aryl bromides bearing diverse functional groups. Oxidation at C‐9 of the dehydroxyquinines expediently provided quinine‐inspired pseudo‐natural products (‘quinalogs’). Investigation of the compound collection against Plasmodium falciparum revealed a new insight into the structure activity relationship of quini… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
2

Relationship

0
2

Authors

Journals

citations
Cited by 2 publications
references
References 59 publications
0
0
0
Order By: Relevance