Synthesis of quinoline based molecular probes for detection of nitric oxide

Synthesis of Triazolo[4′,5′:4,5]furo[2,3-c]pyridine via Post Modification of an Unusual Groebke–Blackburn–Bienaymé Multicomponent Reaction

“…The 1,2,3-triazole formation via diazotization of ortho-diamines on six-membered rings is reported in the literature, ,− but no report was observed wherein an ortho -diamine installed on a five-membered heterocycle was utilized for the synthesis of 1,2,3-triazoles. Our attempt for the diazotization of compound 19 using 5 M HCl and 0.5N NaNO 2 (2.0 equiv) solution in water resulted in the formation of desired product 20 in low (30%) yield.…”

“…It is noteworthy to mention that the “unusual GBB-MCR” is the first and the only report that generates 2,3-diamine-substituted furo­[2,3- c ]­pyridines. Encouraged by the structural diversity obtained in the products generated via post modification of classic GBB reaction, we envisioned that the 2,3-diamino-furo­[2,3- c ]­pyridines synthesized via unusual GBB-MCR is amenable for 1,2,3-triazole construction to generate a library of tricyclic heterocycles utilizing nitrosonium-mediated diazotization. − …”

Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

“…254,255 It can be endogenously synthesized by three different isoforms of nitric oxide synthase and plays an important role in numerous physiological and pathological processes, such as neuronal signal transduction, immune response, programmed cell death, vasodilation, inhibition of protein and DNA damage, and endothelial dysfunction. 256–262 Moreover, maintaining NO homeostasis reduces the risk of cancer and neurodegenerative diseases. 263,264…”

“…254,255 It can be endogenously synthesized by three different isoforms of nitric oxide synthase and plays an important role in numerous physiological and pathological processes, such as neuronal signal transduction, immune response, programmed cell death, vasodilation, inhibition of protein and DNA damage, and endothelial dysfunction. [256][257][258][259][260][261][262] Moreover, maintaining NO homeostasis reduces the risk of cancer and neurodegenerative diseases. 263,264 Gong et al on the basis of maintaining the rigid planar structure of rhodamine B, designed and prepared an efficient near-infrared dye HN7 by expanding the polyconjugated system of rhodamine B.…”

Hantzsch Ester Modified Asymmetric BODIPY Probe with Ultra‐high Sensitivity for Ultra‐fast Detection of Endogenous Hypochlorite in Living Cells

“…Fluorescence imaging, as a non‐invasive in vivo imaging technique, has been extensively developed in recent years due to its intuitive visualization research ability with simple operation and high spatiotemporal resolution. Rational designed fluorescent probes have performed admirably in rapid real‐time monitoring the expression levels of important reactive small molecules, [ 15‐19 ] proteins [ 20‐22 ] and nucleic acids [ 23‐24 ] in a highly sensitive and selective manner. To date, ClO – specific recognition fluorescent probes reported in literatures are equipped with various recognition groups, such as the double carbon bond, [ 25‐26 ] thioether, [ 27 ] thiophene, [ 28 ] hydrazine/hydrazide, [ 29‐30 ] hydrazone, [ 31‐32 ] benzothiazole, [ 33 ] phenothiazine, [ 34‐35 ] oxime, [ 36‐37 ] phosphine, [ 38 ] etc .…”