Synthesis of Quinolone Substituted Pyrazoles, Isoxazoles and Pyridines as a Potential Blue Luminophors

Toche, Raghunath B.; Kazi, Muddassar A.; Patil, Shivaraj P.; Kanawade, Shrikant B.; Jachak, Madhukar N.

doi:10.1007/s10895-010-0654-9

Cited by 10 publications

(4 citation statements)

References 12 publications

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“…Acetylpyrazole was obtained by reaction with hydrazine hydrate in the presence of acetic acid. In contrast to the method in [17], the substance was isolated by extraction from ethyl acetate. The yield was 29%.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of N-heterocycles based on chalcones and their antioxidant properties

Primerova,

Koshelev

2024

Third International Scientific and Practical Symposium on Materials Science and Technology (MST-III 2023)

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In this work, a chalcone obtained from acetylcoumarin and vanillin was used as a starting compound for the synthesis of new effective antioxidants. A preparative method has been developed for the preparation of pyrazole and pyridine derivatives by the reaction of chalcone with hydrazine hydrate and malonodinitrile; the product yields were 29 and 61%. The synthesized substances were characterized by IR spectrometry, mass spectrometry and NMR spectroscopy. The antioxidant ability of the obtained substances was studied in comparison with 4-methyl-2,6-di-tert-butylphenol, including Fe-reducing ability and antiradical activity. The resulting compounds in both methods showed better results compared to the commercial antioxidant.

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Section: Resultsmentioning

confidence: 99%

Synthesis of N-heterocycles based on chalcones and their antioxidant properties

Primerova,

Koshelev

2024

Third International Scientific and Practical Symposium on Materials Science and Technology (MST-III 2023)

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“…Pyridine derivatives synthesis from dimedone. [84] Scheme 45. Different pyridine and 1,4-dihydropyridine derivatives synthesis.…”

Section: Benzoacridinone Derivatives Synthesismentioning

confidence: 99%

“…(Scheme 44). [84] Ezzati et al disclosed the synthesis of new type of 4-aroyl-3methyl-1-phenyl-1,6,7,8-tetrahydro-5H-pyrazolo [3,4-b]quinolin-5-one derivatives 58 by one-pot treatment of cyclic-1,3-diones with arylglyoxals, and methyl-1-phenyl-1H-pyrazol-5-amine at room temperature to reflux conditions to produce desired products. These products were also achieved through 4-aroyl-3-methyl-1-phenyl-1,4,6,7,8,9-hexahydro-5H-pyrazolo [3,4-b]quinolin-5-one derivatives 57 in two step procedure (Scheme 45).…”

Section: Pyridine Derivatives Synthesismentioning

confidence: 99%

“…[83] Quinolones are also significant class of nitrogen-containing heterocycles that display fascinating biological activities, such as antiinflammatory, anticancer, selective progesterone, glucocorticoid receptor modulators, and blue luminophores. [84] These N-heterocycles are prepared from cyclohexane-1,3-dione derivatives as one of the substrates using catalysts such as zinc oxide, polymer supported PEG-SO 3 H, organocatalyst vitamin B 1 , and stepwise synthesis reported in literature. [85,86] Few biologically active benzoacridinones, pyridine and quinolone derivatives are shown in figure 3.…”

Section: Introductionmentioning

confidence: 99%

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Application of Cyclohexane‐1,3‐diones in the Synthesis of Six‐Membered Nitrogen‐Containing Heterocycles

Sharma¹,

Kumar

et al. 2022

ChemistrySelect

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Cyclohexane‐1,3‐dione and its derivatives are imperative precursors in synthetic organic chemistry as they are useful intermediates for the synthesis of a wide range of biologically active natural products, heterocycles and pharmaceuticals. Recently, cyclohexane‐1,3‐diones have been used for the synthesis of varied array of six‐membered nitrogen‐containing heterocycles in the presence of aldehydes, acetoacetic esters, malononitrile, chalcones, coumarins, acetophenones, amino acids, amines, etc. under catalytic and non‐catalytic conditions. Newest studies on the importance of these heterocycles motivated us to compile all the recently developed processes which include the fabrication of six‐membered nitrogen heterocycles. This article is mainly focused on the efficient synthesis of six‐membered N‐heterocycles i. e. 1,4‐dihydropyridine, acridine‐1,8‐diones, benzoacridinones, quinolones and pyridine derivatives from cyclohexane‐1,3‐diones as one of the substrates, published for the last ten years.

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Synthesis and some enzyme inhibition effects of isoxazoline and pyrazoline derivatives including benzonorbornene unit

Yavari

Adiloglu

Kaya

et al. 2021

J Biochem & Molecular Tox

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Four new and four known isoxazoline derivatives were synthesized from the reactions of benzonorbornadiene with nitrile oxides formed from the corresponding benzaldehydes. Three new and one known pyrazoline derivatives were also synthesized from the reactions of the benzonorbornadiene with nitrile imines formed from the corresponding compounds. The synthesized nitrogenbased novel heterocyclic compounds were evaluated against the human carbonic anhydrase isoenzymes I and II (hCA I and hCA II), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The synthesized nitrogenbased novel heterocyclic compounds showed IC 50 values in the range of 2.69-7.01 against hCA I, 2.40-4.59 against hCA II, 0.81-1.32 µM against AChE, and 20.83-1.70 µM against BChE enzymes. On the contrary, nitrogen-based novel heterocyclic compounds demonstrated K i values between2.93 ± 0.59-8.61 ± 1.39 against hCA I, 2.05 ± 0.62-4.97 ± 0.95 against hCA II, 0.34 ± 0.02-0.92 ± 0.17 nM against AChE, and 0.50 ± 0.04-1.20 ± 0.16 µM against BChE enzymes. The synthesized nitrogen-based novel heterocyclic compounds exhibited effective inhibition profiles against both indicated metabolic enzymes. These results may contribute to the development of new drugs particularly to treat some disorders, which are widespread in the world including glaucoma and Alzheimer's diseases.

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Synthesis of Quinolone Substituted Pyrazoles, Isoxazoles and Pyridines as a Potential Blue Luminophors

Cited by 10 publications

References 12 publications

Synthesis of N-heterocycles based on chalcones and their antioxidant properties

Synthesis of N-heterocycles based on chalcones and their antioxidant properties

Application of Cyclohexane‐1,3‐diones in the Synthesis of Six‐Membered Nitrogen‐Containing Heterocycles

Synthesis and some enzyme inhibition effects of isoxazoline and pyrazoline derivatives including benzonorbornene unit

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